Atlas One · Host Biology · Scale 03 — Molecular

STK11

STK11 (LKB1) is a master serine/threonine kinase activating AMPK and 12 related kinases; LOF → mTOR hyperactivation + loss of STING innate immunity; germline STK11 = Peutz-Jeghers syndrome; somatic STK11 in KRAS-mutant NSCLC → immunotherapy resistance (cold tumor).

Also known as: STK11, LKB1, STK11 mutation, STK11 NSCLC, LKB1 NSCLC, STK11 Peutz-Jeghers, STK11 immunotherapy resistance, LKB1 AMPK, STK11 tumor suppressor, STK11 KRAS NSCLC

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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stk11

STK11

STK11 (LKB1) is a master serine/threonine kinase activating AMPK and 12 related kinases; LOF → mTOR hyperactivation + loss of STING innate immunity; germline STK11 = Peutz-Jeghers syndrome; somatic STK11 in KRAS-mutant NSCLC → immunotherapy resistance (cold tumor).

Entry Metadata

FieldValue
IDstk11
NameSTK11
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAmpk connects-toMtor connects-toKras connects-toPd 1

Sources