Atlas One · Host Biology · Scale 07 — System

Hereditary Diffuse Gastric Cancer

Hereditary diffuse gastric cancer (HDGC) is caused by germline CDH1 (~25%) or CTNNA1 (~2-5%) mutations; diffuse/signet ring histology; lifetime GC risk ~83% (CDH1 male); prophylactic gastrectomy is recommended; lobular breast cancer risk is elevated in CDH1/CTNNA1 carriers.

Also known as: HDGC, hereditary diffuse gastric cancer, CDH1 gastric cancer, CTNNA1 HDGC, diffuse gastric cancer hereditary, signet ring cell hereditary, E-cadherin gastric cancer, CDH1 prophylactic gastrectomy, HDGC lobular breast cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hereditary-diffuse-gastric-cancer

Hereditary Diffuse Gastric Cancer

Hereditary diffuse gastric cancer (HDGC) is caused by germline CDH1 (~25%) or CTNNA1 (~2-5%) mutations; diffuse/signet ring histology; lifetime GC risk ~83% (CDH1 male); prophylactic gastrectomy is recommended; lobular breast cancer risk is elevated in CDH1/CTNNA1 carriers.

Entry Metadata

FieldValue
IDhereditary-diffuse-gastric-cancer
NameHereditary Diffuse Gastric Cancer
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCtnna1 connects-toCdh1 connects-toGastric Cancer connects-toBreast Cancer connects-toStomach connects-toCtnnb1 connects-toLynch Syndrome connects-toFap connects-toPeutz Jeghers Syndrome connects-toJuvenile Polyposis Syndrome connects-toDigestive System connects-toIntestinal Epithelium connects-toColorectal Cancer connects-toHereditary Breast Ovarian Cancer connects-toEsophageal Cancer connects-toCowden Syndrome connects-toHelicobacter Pylori connects-toWnt Beta Catenin connects-toFibroblast connects-toReproductive System connects-toOvarian Cancer connects-toImmune System connects-toLymphatic System connects-toSmooth Muscle Cell connects-toPhoton connects-toEstrogen connects-toHer2 connects-toRegulatory T Cell connects-toCalcium connects-toMacrophage connects-toTgf Beta connects-toLiver connects-toEndothelial Cell connects-toOxygen connects-toIron connects-toLarge Intestine connects-toFibrosis connects-toElectron connects-toBone Marrow connects-toLung connects-toAntibody connects-toErythrocyte connects-toNeuron connects-toSmall Intestine connects-toAdipocyte connects-toPlatelet connects-toP53 connects-toT Cytotoxic Cell connects-toLi Fraumeni Syndrome connects-toIron Deficiency Anemia connects-toCdkn2A connects-toVenous Thromboembolism connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toCkd connects-toGeneralized Anxiety Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toEndocrine System connects-toMusculoskeletal System connects-toNervous System connects-toIntegumentary System connects-toRespiratory System connects-toCardiovascular System connects-toMutyh Associated Polyposis connects-toVitamin D connects-toZinc Dietary connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toCheckpoint Inhibitors connects-toRetinoblastoma connects-toDesmoid Tumor connects-toDietary Fiber connects-toHepatic Lobule connects-toCortical Bone connects-toAlveolus connects-toPancreatic Cancer connects-toCholangiocarcinoma connects-toProstate Cancer connects-toFgfr connects-toPik3Ca connects-toMet connects-toAkt connects-toHif 1Alpha connects-toMyc connects-toSrc Kinase connects-toTert connects-toCcl2 connects-toCaspase 3 connects-toYap1 connects-toCxcl12 connects-toCollagen connects-toPerforin connects-toVegf connects-toErk1 2 connects-toMtor connects-toE2F1 connects-toMyd88 connects-toSmad4 connects-toIl 6 connects-toGalectin 3 connects-toJak1 2 connects-toPten connects-toStat1 connects-toCgas Sting connects-toCdk4 6 connects-toFoxo connects-toMdm2 connects-toS100A8 A9 connects-toGsk 3B connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toAxl Receptor connects-toMhc Class Ii connects-toPd 1 connects-toHemoglobin connects-toIl 2 connects-toIl 10 connects-toIl 4 connects-toXanthine Oxidase connects-toProstaglandins connects-toIl 13 connects-toT Cytotoxic Cell connects-toIron connects-toLeptin connects-toAdiponectin connects-toHepcidin connects-toResistin connects-toNatural Killer Cell connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toZinc connects-toMagnesium connects-toIodine connects-toSodium connects-toCopper connects-toChloride connects-toNitrogen connects-toPhosphorus connects-toCarbon connects-toHydrogen connects-toPotassium connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin

Sources