Atlas One · Host Biology · Scale 07 — System

Hereditary Diffuse Gastric Cancer

Hereditary diffuse gastric cancer (HDGC) is caused by germline CDH1 (~25%) or CTNNA1 (~2-5%) mutations; diffuse/signet ring histology; lifetime GC risk ~83% (CDH1 male); prophylactic gastrectomy is recommended; lobular breast cancer risk is elevated in CDH1/CTNNA1 carriers.

Also known as: HDGC, hereditary diffuse gastric cancer, CDH1 gastric cancer, CTNNA1 HDGC, diffuse gastric cancer hereditary, signet ring cell hereditary, E-cadherin gastric cancer, CDH1 prophylactic gastrectomy, HDGC lobular breast cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hereditary-diffuse-gastric-cancer

Hereditary Diffuse Gastric Cancer

Hereditary diffuse gastric cancer (HDGC) is caused by germline CDH1 (~25%) or CTNNA1 (~2-5%) mutations; diffuse/signet ring histology; lifetime GC risk ~83% (CDH1 male); prophylactic gastrectomy is recommended; lobular breast cancer risk is elevated in CDH1/CTNNA1 carriers.

Entry Metadata

FieldValue
IDhereditary-diffuse-gastric-cancer
NameHereditary Diffuse Gastric Cancer
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCtnna1 connects-toCdh1 connects-toGastric Cancer connects-toBreast Cancer connects-toStomach connects-toCtnnb1 connects-toLynch Syndrome connects-toFap connects-toPeutz Jeghers Syndrome connects-toJuvenile Polyposis Syndrome connects-toDigestive System connects-toIntestinal Epithelium connects-toColorectal Cancer

Sources