Atlas One · Host Biology · Scale 07 — System

Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome (HBOC) is caused by germline BRCA1/2, PALB2, ATM, or CHEK2 variants; BRCA1 lifetime breast risk ~70%, ovarian ~44%; PARP inhibitors approved across cancer types; risk-reducing surgery (mastectomy/BSO) is standard.

Also known as: HBOC, hereditary breast and ovarian cancer, BRCA syndrome, BRCA1 BRCA2 syndrome, hereditary breast cancer, germline BRCA, HBOC syndrome, BRCA1 germline, familial breast cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hereditary-breast-ovarian-cancer

Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome (HBOC) is caused by germline BRCA1/2, PALB2, ATM, or CHEK2 variants; BRCA1 lifetime breast risk ~70%, ovarian ~44%; PARP inhibitors approved across cancer types; risk-reducing surgery (mastectomy/BSO) is standard.

Entry Metadata

FieldValue
IDhereditary-breast-ovarian-cancer
NameHereditary Breast and Ovarian Cancer
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPalb2 connects-toBrca1 connects-toBrca2 connects-toOvarian Cancer connects-toAtm connects-toRad51 connects-toBreast Cancer connects-toLi Fraumeni Syndrome connects-toPancreatic Cancer connects-toProstate Cancer connects-toMelanoma connects-toReproductive System treated-byTargeted Therapy

Sources