Atlas One · Host Biology · Scale 07 — System

Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome (HBOC) is caused by germline BRCA1/2, PALB2, ATM, or CHEK2 variants; BRCA1 lifetime breast risk ~70%, ovarian ~44%; PARP inhibitors approved across cancer types; risk-reducing surgery (mastectomy/BSO) is standard.

Also known as: HBOC, hereditary breast and ovarian cancer, BRCA syndrome, BRCA1 BRCA2 syndrome, hereditary breast cancer, germline BRCA, HBOC syndrome, BRCA1 germline, familial breast cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hereditary-breast-ovarian-cancer

Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome (HBOC) is caused by germline BRCA1/2, PALB2, ATM, or CHEK2 variants; BRCA1 lifetime breast risk ~70%, ovarian ~44%; PARP inhibitors approved across cancer types; risk-reducing surgery (mastectomy/BSO) is standard.

Entry Metadata

FieldValue
IDhereditary-breast-ovarian-cancer
NameHereditary Breast and Ovarian Cancer
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPalb2 connects-toBrca1 connects-toBrca2 connects-toOvarian Cancer connects-toAtm connects-toRad51 connects-toBreast Cancer connects-toLi Fraumeni Syndrome connects-toPancreatic Cancer connects-toProstate Cancer connects-toMelanoma connects-toReproductive System treated-byTargeted Therapy connects-toLynch Syndrome connects-toCowden Syndrome connects-toPeutz Jeghers Syndrome connects-toEstrogen connects-toEndometrial Cancer connects-toPhoton connects-toP53 connects-toBloom Syndrome connects-toImmune System connects-toCdh1 connects-toMutyh Associated Polyposis connects-toT Cytotoxic Cell connects-toProgesterone connects-toHer2 connects-toRegulatory T Cell connects-toPancreas connects-toVegf connects-toNatural Killer Cell connects-toEndothelial Cell connects-toBone Marrow connects-toSkin connects-toFibroblast connects-toFibrosis connects-toCalcium connects-toElectron connects-toBrain connects-toLiver connects-toErythrocyte connects-toNeuron connects-toAntibody connects-toPlatelet connects-toMds connects-toOsteoporosis connects-toPik3Ca connects-toDendritic Cell connects-toCholangiocarcinoma connects-toGastric Cancer connects-toAml connects-toMyc connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toMajor Depressive Disorder connects-toHeart Failure connects-toCkd connects-toGeneralized Anxiety Disorder connects-toNeuropathic Pain connects-toAspergillus Fumigatus connects-toWound Healing connects-toEndocrine System connects-toDigestive System connects-toCardiovascular System connects-toLymphatic System connects-toNervous System connects-toIntegumentary System connects-toMusculoskeletal System connects-toRespiratory System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toRothmund Thomson connects-toFap connects-toRetinoblastoma connects-toCervical Cancer connects-toWerner Syndrome connects-toAplastic Anemia connects-toOvarian Clear Cell Carcinoma connects-toUveal Melanoma connects-toCortical Bone connects-toMyocardium connects-toCdk4 6 connects-toAkt connects-toMtor connects-toHif 1Alpha connects-toEzh2 connects-toTert connects-toPd 1 connects-toCdkn2A connects-toCcl2 connects-toRankl connects-toCgas Sting connects-toCxcl12 connects-toCaspase 3 connects-toPerforin connects-toAndrogen Receptor connects-toPten connects-toE2F1 connects-toEgfr connects-toMdm2 connects-toRb1 connects-toBcl 2 connects-toGalectin 3 connects-toTgf Beta connects-toErk1 2 connects-toStat1 connects-toStat3 connects-toSmad4 connects-toFoxo connects-toS100A8 A9 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 6 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toIl 2 connects-toAxl Receptor connects-toHemoglobin connects-toIl 10 connects-toXanthine Oxidase connects-toProstaglandins connects-toIl 4 connects-toIron connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toMelanoma connects-toT Cytotoxic Cell connects-toHereditary Diffuse Gastric Cancer connects-toType I Interferon connects-toMacrophage connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toPlasma Cell connects-toB Cell connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toZinc connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine

Sources