Atlas One · Host Biology · Scale 07 — System

Retinoblastoma

Retinoblastoma is the most common intraocular childhood tumor (1/15,000); bilateral = germline RB1; unilateral = usually somatic; leukocoria is the classic presentation; intra-arterial/intravitreal chemotherapy preserves vision; hereditary RB1 confers osteosarcoma risk.

Also known as: retinoblastoma, RB1 tumor, bilateral retinoblastoma, hereditary retinoblastoma, RBL, retinoblastoma leukocoria, intraocular tumor child, retinoblastoma treatment, retinoblastoma genetics

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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retinoblastoma

Retinoblastoma

Retinoblastoma is the most common intraocular childhood tumor (1/15,000); bilateral = germline RB1; unilateral = usually somatic; leukocoria is the classic presentation; intra-arterial/intravitreal chemotherapy preserves vision; hereditary RB1 confers osteosarcoma risk.

Entry Metadata

FieldValue
IDretinoblastoma
NameRetinoblastoma
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toE2F1 connects-toRb1 connects-toP53 connects-toOsteosarcoma connects-toEye connects-toMycn connects-toMdm2 connects-toNeuron connects-toBrain connects-toLi Fraumeni Syndrome

Sources