Atlas One · Host Biology · Scale 03 — Molecular

MYCN

MYCN (N-Myc) is an amplified bHLH-LZ TF in ~20% neuroblastoma (~40% high-risk); heterodimerizes with MAX → drives ribosome biogenesis, TERT, cell cycle; AURKA stabilizes MYCN protein; MYCN amplification predicts poor prognosis; AURKA/BET inhibitors target MYCN indirectly.

Also known as: MYCN, N-Myc, MYCN amplification, N-myc oncogene, MYCN neuroblastoma, NMYC, MYCN NEPC

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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mycn

MYCN

MYCN (N-Myc) is an amplified bHLH-LZ TF in ~20% neuroblastoma (~40% high-risk); heterodimerizes with MAX → drives ribosome biogenesis, TERT, cell cycle; AURKA stabilizes MYCN protein; MYCN amplification predicts poor prognosis; AURKA/BET inhibitors target MYCN indirectly.

Entry Metadata

FieldValue
IDmycn
NameMYCN
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMyc connects-toAlk connects-toTert connects-toP53

Sources