Atlas One · Host Biology · Scale 07 — System

Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor; peak 10-20 years; RB1 biallelic loss ~70-75%, TP53 ~30-40%, MDM2 amplification ~6-8%, CDKN2A deletion ~20-30%; MAP protocol (methotrexate+doxorubicin+cisplatin); localized 5-year OS ~70-75%; metastatic ~20-25%.

Also known as: osteosarcoma, OSA, OS bone, osteogenic sarcoma, high-grade osteosarcoma, MAP protocol bone tumor, pediatric bone cancer, conventional osteosarcoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
osteosarcoma

Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor; peak 10-20 years; RB1 biallelic loss ~70-75%, TP53 ~30-40%, MDM2 amplification ~6-8%, CDKN2A deletion ~20-30%; MAP protocol (methotrexate+doxorubicin+cisplatin); localized 5-year OS ~70-75%; metastatic ~20-25%.

Entry Metadata

FieldValue
IDosteosarcoma
NameOsteosarcoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn2A connects-toRb1 connects-toP53 connects-toMdm2 connects-toOsteoblast connects-toRetinoblastoma connects-toIgf 1 connects-toLi Fraumeni Syndrome connects-toMusculoskeletal System connects-toLung

Sources