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osteosarcoma
Osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor; peak 10-20 years; RB1 biallelic loss ~70-75%, TP53 ~30-40%, MDM2 amplification ~6-8%, CDKN2A deletion ~20-30%; MAP protocol (methotrexate+doxorubicin+cisplatin); localized 5-year OS ~70-75%; metastatic ~20-25%.
Entry Metadata
| Field | Value |
|---|---|
| ID | osteosarcoma |
| Name | Osteosarcoma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toCdkn2A
connects-toRb1
connects-toP53
connects-toMdm2
connects-toOsteoblast
connects-toRetinoblastoma
connects-toIgf 1
connects-toLi Fraumeni Syndrome
connects-toMusculoskeletal System
connects-toLung
connects-toEwing Sarcoma
connects-toOsteoclast
connects-toRothmund Thomson
connects-toMpnst
connects-toCalcium
connects-toPhoton
connects-toFibroblast
connects-toVegf
connects-toMtor
connects-toProton
connects-toCarbon
connects-toCollagen
connects-toHer2
connects-toMacrophage
connects-toBone Marrow
connects-toPhosphorus
connects-toNatural Killer Cell
connects-toEzh2
connects-toOxygen
connects-toAkt
connects-toT Cytotoxic Cell
connects-toEndothelial Cell
connects-toKidney
connects-toFibrosis
connects-toElectron
connects-toZinc
connects-toPlatelet
connects-toHeart
connects-toGrowth Hormone
connects-toNeuron
connects-toAntibody
connects-toNeutrophil
connects-toMagnesium
connects-toReproductive System
connects-toTert
connects-toRegulatory T Cell
connects-toRankl
connects-toCdk4 6
connects-toAtrx
connects-toMyc
connects-toCardiomyocyte
connects-toNeuropathic Pain
connects-toStat3
connects-toVenous Thromboembolism
connects-toSepsis
connects-toHeart Failure
connects-toCkd
connects-toMajor Depressive Disorder
connects-toWound Healing
connects-toAspergillus Fumigatus
connects-toGeneralized Anxiety Disorder
connects-toRespiratory System
connects-toVaricella Zoster Virus
connects-toDigestive System
connects-toRenal System
connects-toCardiovascular System
connects-toNervous System
connects-toImmune System
connects-toEndocrine System
connects-toTargeted Therapy
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toCheckpoint Inhibitors
connects-toAlveolus
connects-toMyocardium
connects-toRhabdomyosarcoma
connects-toWerner Syndrome
connects-toBloom Syndrome
connects-toHepatic Lobule
connects-toMultiple Myeloma
connects-toAml
connects-toWnt Beta Catenin
connects-toPdgf
connects-toYap1
connects-toHif 1Alpha
connects-toCyclin D1
connects-toNotch
connects-toFgfr
connects-toSrc Kinase
connects-toCxcl12
connects-toRad51
connects-toCaspase 3
connects-toOsteopontin
connects-toCcl2
connects-toTgf Beta
connects-toIl 6
connects-toMet
connects-toE2F1
connects-toPik3Ca
connects-toErk1 2
connects-toJak1 2
connects-toBcl 2
connects-toKras
connects-toGalectin 3
connects-toSmad4
connects-toPten
connects-toStat1
connects-toCgas Sting
connects-toFoxo
connects-toGsk 3B
connects-toS100A8 A9
connects-toPerforin
connects-toDnmt3A
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toArid1A
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toComplement C3
connects-toPth
connects-toAxl Receptor
connects-toMhc Class Ii
connects-toIl 2
connects-toTroponin Complex
connects-toPd 1
connects-toHemoglobin
connects-toXanthine Oxidase
connects-toIl 10
connects-toProstaglandins
connects-toIl 4
connects-toIron
connects-toIl 13
connects-toCopper
connects-toNitric Oxide
connects-toLeptin
connects-toAdiponectin
connects-toCalcium
connects-toResistin
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toDendritic Cell
connects-toT Helper Cell
connects-toB Cell
connects-toC5Ar1
connects-toErythropoietin
connects-toBradykinin
connects-toComplement C5
connects-toTslp
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toPotassium
connects-toChloride
connects-toSulfur
connects-toHydrogen
connects-toNitrogen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toFibronectin
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
connects-toAngiopoietin
connects-toCortisol
Sources
- Bielack SS, Kempf-Bielack B, Delling G, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol. 2002;20(3):776-790. · PubMed 11821461
- Marina NM, Smeland S, Bielack SS, et al. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1). Lancet Oncol. 2016;17(10):1396-1408. · PubMed 27569442