Atlas One · Host Biology · Scale 07 — System

Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor; peak 10-20 years; RB1 biallelic loss ~70-75%, TP53 ~30-40%, MDM2 amplification ~6-8%, CDKN2A deletion ~20-30%; MAP protocol (methotrexate+doxorubicin+cisplatin); localized 5-year OS ~70-75%; metastatic ~20-25%.

Also known as: osteosarcoma, OSA, OS bone, osteogenic sarcoma, high-grade osteosarcoma, MAP protocol bone tumor, pediatric bone cancer, conventional osteosarcoma

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
osteosarcoma

Osteosarcoma

Osteosarcoma is the most common primary malignant bone tumor; peak 10-20 years; RB1 biallelic loss ~70-75%, TP53 ~30-40%, MDM2 amplification ~6-8%, CDKN2A deletion ~20-30%; MAP protocol (methotrexate+doxorubicin+cisplatin); localized 5-year OS ~70-75%; metastatic ~20-25%.

Entry Metadata

FieldValue
IDosteosarcoma
NameOsteosarcoma
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn2A connects-toRb1 connects-toP53 connects-toMdm2 connects-toOsteoblast connects-toRetinoblastoma connects-toIgf 1 connects-toLi Fraumeni Syndrome connects-toMusculoskeletal System connects-toLung connects-toEwing Sarcoma connects-toOsteoclast connects-toRothmund Thomson connects-toMpnst connects-toCalcium connects-toPhoton connects-toFibroblast connects-toVegf connects-toMtor connects-toProton connects-toCarbon connects-toCollagen connects-toHer2 connects-toMacrophage connects-toBone Marrow connects-toPhosphorus connects-toNatural Killer Cell connects-toEzh2 connects-toOxygen connects-toAkt connects-toT Cytotoxic Cell connects-toEndothelial Cell connects-toKidney connects-toFibrosis connects-toElectron connects-toZinc connects-toPlatelet connects-toHeart connects-toGrowth Hormone connects-toNeuron connects-toAntibody connects-toNeutrophil connects-toMagnesium connects-toReproductive System connects-toTert connects-toRegulatory T Cell connects-toRankl connects-toCdk4 6 connects-toAtrx connects-toMyc connects-toCardiomyocyte connects-toNeuropathic Pain connects-toStat3 connects-toVenous Thromboembolism connects-toSepsis connects-toHeart Failure connects-toCkd connects-toMajor Depressive Disorder connects-toWound Healing connects-toAspergillus Fumigatus connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toVaricella Zoster Virus connects-toDigestive System connects-toRenal System connects-toCardiovascular System connects-toNervous System connects-toImmune System connects-toEndocrine System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toCortical Bone connects-toCheckpoint Inhibitors connects-toAlveolus connects-toMyocardium connects-toRhabdomyosarcoma connects-toWerner Syndrome connects-toBloom Syndrome connects-toHepatic Lobule connects-toMultiple Myeloma connects-toAml connects-toWnt Beta Catenin connects-toPdgf connects-toYap1 connects-toHif 1Alpha connects-toCyclin D1 connects-toNotch connects-toFgfr connects-toSrc Kinase connects-toCxcl12 connects-toRad51 connects-toCaspase 3 connects-toOsteopontin connects-toCcl2 connects-toTgf Beta connects-toIl 6 connects-toMet connects-toE2F1 connects-toPik3Ca connects-toErk1 2 connects-toJak1 2 connects-toBcl 2 connects-toKras connects-toGalectin 3 connects-toSmad4 connects-toPten connects-toStat1 connects-toCgas Sting connects-toFoxo connects-toGsk 3B connects-toS100A8 A9 connects-toPerforin connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toPth connects-toAxl Receptor connects-toMhc Class Ii connects-toIl 2 connects-toTroponin Complex connects-toPd 1 connects-toHemoglobin connects-toXanthine Oxidase connects-toIl 10 connects-toProstaglandins connects-toIl 4 connects-toIron connects-toIl 13 connects-toCopper connects-toNitric Oxide connects-toLeptin connects-toAdiponectin connects-toCalcium connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toDendritic Cell connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toErythropoietin connects-toBradykinin connects-toComplement C5 connects-toTslp connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toChloride connects-toSulfur connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toFibronectin connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toCortisol