Atlas One · Host Biology · Scale 03 — Molecular

ATRX

ATRX is a chromatin remodeler of the ATRX-DAXX-H3.3 complex at telomeres; LOF causes alternative lengthening of telomeres (ALT); mutated in ~80% of IDH-mutant astrocytoma (Grade 3/4), MPNST, pancreatic NETs, neuroblastoma; ATRX LOF + IDH1 = astrocytoma lineage; 1p/19q intact.

Also known as: ATRX, ATRX mutation, ATRX glioma, ATRX astrocytoma, ALT ATRX, alternative lengthening of telomeres, ATRX-DAXX complex, ATRX LOF, ATRX IHC, ATRX chromatin remodeler

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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atrx

ATRX

ATRX is a chromatin remodeler of the ATRX-DAXX-H3.3 complex at telomeres; LOF causes alternative lengthening of telomeres (ALT); mutated in ~80% of IDH-mutant astrocytoma (Grade 3/4), MPNST, pancreatic NETs, neuroblastoma; ATRX LOF + IDH1 = astrocytoma lineage; 1p/19q intact.

Entry Metadata

FieldValue
IDatrx
NameATRX
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toIdh1 connects-toTet2 connects-toP53 connects-toCdkn2A connects-toTert connects-toGlioblastoma connects-toNeuroendocrine Tumors

Sources