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il-5
Interleukin-5
IL-5 (IL5, chr5q31.1) is a Th2 homodimer cytokine selectively driving eosinophil differentiation, survival, and recruitment via IL-5Rα/βc → JAK1/JAK2 → STAT5; mepolizumab and benralizumab (anti-IL-5/IL-5Rα) reduce eosinophilic asthma exacerbations 47-50%.
Entry Metadata
| Field | Value |
|---|---|
| ID | il-5 |
| Name | Interleukin-5 |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198-1207. · PubMed 25199059
- FitzGerald JM, Bleecker ER, Nair P, et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2115-2127. · PubMed 27609408