Atlas One · Host Biology · Scale 07 — System

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is caused by germline TP53 mutations; spectrum of sarcoma, brain tumors, breast cancer, and adrenocortical carcinoma; radiation avoidance is critical; whole-body MRI annual surveillance; TP53 is the most commonly mutated gene in all cancers.

Also known as: Li-Fraumeni syndrome, LFS, TP53 germline, germline TP53 mutation, SBLA syndrome, Li-Fraumeni, LFS surveillance, hereditary TP53, TP53 hereditary cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
li-fraumeni-syndrome

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is caused by germline TP53 mutations; spectrum of sarcoma, brain tumors, breast cancer, and adrenocortical carcinoma; radiation avoidance is critical; whole-body MRI annual surveillance; TP53 is the most commonly mutated gene in all cancers.

Entry Metadata

FieldValue
IDli-fraumeni-syndrome
NameLi-Fraumeni Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn1A connects-toP53 connects-toMdm2 connects-toOsteosarcoma connects-toBreast Cancer connects-toAdrenal Gland connects-toMedulloblastoma connects-toHereditary Breast Ovarian Cancer connects-toRhabdomyosarcoma connects-toAll connects-toPhoton connects-toGlioblastoma connects-toAml connects-toPancreatic Cancer connects-toColorectal Cancer connects-toFibroblast connects-toAtm connects-toEwing Sarcoma connects-toNsclc connects-toCdkn2A connects-toImmune System connects-toNervous System connects-toBrca1 connects-toGastric Cancer connects-toMelanoma connects-toCaspase 3 connects-toRb1 connects-toNatural Killer Cell connects-toBrain connects-toT Cytotoxic Cell connects-toMtor connects-toBone Marrow connects-toOsteoblast connects-toOxygen connects-toSmooth Muscle Cell connects-toLiver connects-toPeripheral Nerve connects-toElectron connects-toLung connects-toSkin connects-toAntibody connects-toNeutrophil connects-toThyroid connects-toReproductive System connects-toCyclin D1 connects-toRegulatory T Cell connects-toBcl 2 connects-toOsteoclast connects-toWilms Tumor connects-toNeuroblastoma connects-toProstate Cancer connects-toIgf 1 connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toHeart Failure connects-toMajor Depressive Disorder connects-toAnemia Of Chronic Disease connects-toGeneralized Anxiety Disorder connects-toAspergillus Fumigatus connects-toNeuropathic Pain connects-toEndocrine System connects-toWound Healing connects-toVaricella Zoster Virus connects-toMusculoskeletal System connects-toRespiratory System connects-toIntegumentary System connects-toCardiovascular System connects-toDigestive System connects-toLymphatic System connects-toCancer Chemotherapy connects-toLynch Syndrome connects-toNeurofibromatosis Type 1 connects-toCortical Bone connects-toTargeted Therapy connects-toSynovial Sarcoma connects-toJuvenile Polyposis Syndrome connects-toMyocardium connects-toHepatic Lobule connects-toRetinoblastoma connects-toCowden Syndrome connects-toMeningioma connects-toCdk4 6 connects-toTert connects-toAkt connects-toMyc connects-toHif 1Alpha connects-toVegf connects-toRad51 connects-toAmpk connects-toCcl2 connects-toCgas Sting connects-toAutophagy connects-toCxcl12 connects-toCortisol connects-toXanthine Oxidase connects-toDnmt3A connects-toE2F1 connects-toPten connects-toHer2 connects-toKras connects-toNfe2L2 connects-toEgfr connects-toErk1 2 connects-toPik3Ca connects-toGalectin 3 connects-toStat1 connects-toStat3 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toNotch connects-toArid1A connects-toCcr5 connects-toIl 6 connects-toEzh2 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toIl 2 connects-toPd 1 connects-toHemoglobin connects-toTroponin Complex connects-toIl 10 connects-toProstaglandins connects-toIron connects-toIl 4 connects-toIl 13 connects-toT Cytotoxic Cell connects-toIron connects-toProton connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 23 connects-toIl 5 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toMacrophage connects-toC5Ar1 connects-toTslp connects-toErythropoietin connects-toHistamine connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toCalcium connects-toCarbon connects-toNitrogen connects-toChloride connects-toHydrogen connects-toPhosphorus connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toFibronectin connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr

Sources