Atlas One · Host Biology · Scale 07 — System

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is caused by germline TP53 mutations; spectrum of sarcoma, brain tumors, breast cancer, and adrenocortical carcinoma; radiation avoidance is critical; whole-body MRI annual surveillance; TP53 is the most commonly mutated gene in all cancers.

Also known as: Li-Fraumeni syndrome, LFS, TP53 germline, germline TP53 mutation, SBLA syndrome, Li-Fraumeni, LFS surveillance, hereditary TP53, TP53 hereditary cancer

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
li-fraumeni-syndrome

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is caused by germline TP53 mutations; spectrum of sarcoma, brain tumors, breast cancer, and adrenocortical carcinoma; radiation avoidance is critical; whole-body MRI annual surveillance; TP53 is the most commonly mutated gene in all cancers.

Entry Metadata

FieldValue
IDli-fraumeni-syndrome
NameLi-Fraumeni Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCdkn1A connects-toP53 connects-toMdm2 connects-toOsteosarcoma connects-toBreast Cancer connects-toAdrenal Gland connects-toMedulloblastoma connects-toHereditary Breast Ovarian Cancer connects-toRhabdomyosarcoma connects-toAll connects-toPhoton connects-toGlioblastoma connects-toAml

Sources