Atlas One · Host Biology · Scale 07 — System

Colorectal Cancer

Second leading cause of cancer deaths; driven by APC/Wnt loss → adenoma-carcinoma sequence, then KRAS, SMAD4, and TP53 mutations. EGFR blockade (cetuximab) for RAS-wild-type metastatic disease; KRAS/BRAF V600E inhibitors and pembrolizumab (MSI-H) are molecularly targeted.

Also known as: CRC, colon cancer, rectal cancer, colorectal carcinoma, adenocarcinoma of colon, mCRC, Lynch syndrome, FAP

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
colorectal-cancer

Colorectal Cancer

Second leading cause of cancer deaths; driven by APC/Wnt loss → adenoma-carcinoma sequence, then KRAS, SMAD4, and TP53 mutations. EGFR blockade (cetuximab) for RAS-wild-type metastatic disease; KRAS/BRAF V600E inhibitors and pembrolizumab (MSI-H) are molecularly targeted.

Entry Metadata

FieldValue
IDcolorectal-cancer
NameColorectal Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toKras connects-toWnt Beta Catenin connects-toEgfr connects-toBraf connects-toFibronectin connects-toLarge Intestine connects-toLynch Syndrome connects-toP53 connects-toProstate Cancer connects-toLiver connects-toFap connects-toMutyh Associated Polyposis connects-toInflammatory Bowel Disease connects-toT Cytotoxic Cell connects-toGut Microbiome connects-toObesity connects-toPhoton connects-toApc targetsIntestinal Epithelium connects-toPd 1 connects-toType 2 Diabetes connects-toLung connects-toHer2 connects-toIron Deficiency Anemia connects-toVitamin D connects-toFibroblast connects-toVegf connects-toSmad4 connects-toRegulatory T Cell connects-toCalcium connects-toMacrophage connects-toBrain connects-toIron connects-toEndothelial Cell connects-toFibrosis connects-toElectron connects-toPlatelet connects-toBone Marrow connects-toNeuron connects-toMagnesium connects-toSkin connects-toAntibody connects-toNeutrophil connects-toDietary Fiber connects-toVenous Thromboembolism connects-toCardiomyocyte connects-toPik3Ca connects-toCtnnb1 connects-toEscherichia Coli connects-toHepatocyte connects-toNf Kb connects-toStat3 connects-toSepsis connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toCkd connects-toNeuropathic Pain connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toDigestive System connects-toWound Healing connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toLymphatic System connects-toImmune System connects-toCardiovascular System connects-toIntegumentary System connects-toNervous System connects-toTargeted Therapy connects-toRenal System connects-toReproductive System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toHepatic Lobule connects-toGerminal Center connects-toJuvenile Polyposis Syndrome connects-toPeutz Jeghers Syndrome connects-toAlveolus connects-toEndometrial Cancer connects-toMyocardium connects-toMelanoma connects-toGastric Cancer connects-toOvarian Cancer connects-toProstaglandins connects-toMyc connects-toTgf Beta connects-toAkt connects-toCyclin D1 connects-toHif 1Alpha connects-toMlh1 connects-toCxcl12 connects-toIl 6 connects-toMsh2 connects-toCgas Sting connects-toCcl2 connects-toPten connects-toNotch connects-toCaspase 3 connects-toErk1 2 connects-toMtor connects-toE2F1 connects-toMyd88 connects-toJak1 2 connects-toRb1 connects-toGalectin 3 connects-toStat1 connects-toEzh2 connects-toCdk4 6 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toMhc Class Ii connects-toTransferrin connects-toIgf 1 connects-toIl 2 connects-toHemoglobin connects-toTroponin Complex connects-toCholesterol connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toLeptin connects-toInsulin connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toIron connects-toType I Interferon connects-toSelenium connects-toIfn Gamma connects-toIl 12 connects-toNatural Killer Cell connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toB Cell connects-toT Helper Cell connects-toComplement C3 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toErythropoietin connects-toPeriostin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toProlactin connects-toZinc connects-toIodine connects-toCopper connects-toSodium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin