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colorectal-cancer
Colorectal Cancer
Second leading cause of cancer deaths; driven by APC/Wnt loss → adenoma-carcinoma sequence, then KRAS, SMAD4, and TP53 mutations. EGFR blockade (cetuximab) for RAS-wild-type metastatic disease; KRAS/BRAF V600E inhibitors and pembrolizumab (MSI-H) are molecularly targeted.
Entry Metadata
| Field | Value |
|---|---|
| ID | colorectal-cancer |
| Name | Colorectal Cancer |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toKras
connects-toWnt Beta Catenin
connects-toEgfr
connects-toBraf
connects-toFibronectin
connects-toLarge Intestine
connects-toLynch Syndrome
connects-toP53
connects-toProstate Cancer
connects-toLiver
connects-toFap
connects-toMutyh Associated Polyposis
connects-toInflammatory Bowel Disease
connects-toT Cytotoxic Cell
connects-toGut Microbiome
connects-toObesity
connects-toPhoton
connects-toApc
targetsIntestinal Epithelium
connects-toPd 1
connects-toType 2 Diabetes
connects-toLung
connects-toHer2
connects-toIron Deficiency Anemia
connects-toVitamin D
connects-toFibroblast
connects-toVegf
connects-toSmad4
connects-toRegulatory T Cell
connects-toCalcium
connects-toMacrophage
connects-toBrain
connects-toIron
connects-toEndothelial Cell
connects-toFibrosis
connects-toElectron
connects-toPlatelet
connects-toBone Marrow
connects-toNeuron
connects-toMagnesium
connects-toSkin
connects-toAntibody
connects-toNeutrophil
connects-toDietary Fiber
connects-toVenous Thromboembolism
connects-toCardiomyocyte
connects-toPik3Ca
connects-toCtnnb1
connects-toEscherichia Coli
connects-toHepatocyte
connects-toNf Kb
connects-toStat3
connects-toSepsis
connects-toAnemia Of Chronic Disease
connects-toHeart Failure
connects-toCkd
connects-toNeuropathic Pain
connects-toAspergillus Fumigatus
connects-toMajor Depressive Disorder
connects-toDigestive System
connects-toWound Healing
connects-toGeneralized Anxiety Disorder
connects-toRespiratory System
connects-toLymphatic System
connects-toImmune System
connects-toCardiovascular System
connects-toIntegumentary System
connects-toNervous System
connects-toTargeted Therapy
connects-toRenal System
connects-toReproductive System
connects-toCancer Chemotherapy
connects-toCheckpoint Inhibitors
connects-toHepatic Lobule
connects-toGerminal Center
connects-toJuvenile Polyposis Syndrome
connects-toPeutz Jeghers Syndrome
connects-toAlveolus
connects-toEndometrial Cancer
connects-toMyocardium
connects-toMelanoma
connects-toGastric Cancer
connects-toOvarian Cancer
connects-toProstaglandins
connects-toMyc
connects-toTgf Beta
connects-toAkt
connects-toCyclin D1
connects-toHif 1Alpha
connects-toMlh1
connects-toCxcl12
connects-toIl 6
connects-toMsh2
connects-toCgas Sting
connects-toCcl2
connects-toPten
connects-toNotch
connects-toCaspase 3
connects-toErk1 2
connects-toMtor
connects-toE2F1
connects-toMyd88
connects-toJak1 2
connects-toRb1
connects-toGalectin 3
connects-toStat1
connects-toEzh2
connects-toCdk4 6
connects-toFoxo
connects-toPerforin
connects-toGsk 3B
connects-toMdm2
connects-toS100A8 A9
connects-toSrc Kinase
connects-toDnmt3A
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toArid1A
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toMhc Class Ii
connects-toTransferrin
connects-toIgf 1
connects-toIl 2
connects-toHemoglobin
connects-toTroponin Complex
connects-toCholesterol
connects-toIl 10
connects-toXanthine Oxidase
connects-toIl 4
connects-toLeptin
connects-toInsulin
connects-toIl 13
connects-toAdiponectin
connects-toResistin
connects-toIron
connects-toType I Interferon
connects-toSelenium
connects-toIfn Gamma
connects-toIl 12
connects-toNatural Killer Cell
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toB Cell
connects-toT Helper Cell
connects-toComplement C3
connects-toC5Ar1
connects-toDendritic Cell
connects-toTslp
connects-toErythropoietin
connects-toPeriostin
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toOxytocin
connects-toVasopressin
connects-toProlactin
connects-toZinc
connects-toIodine
connects-toCopper
connects-toSodium
connects-toPotassium
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toRankl
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
Sources
- Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12-49. · PubMed 38230766
- Van Cutsem E, Köhne CH, Láng I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011;29(15):2011-2019. · PubMed 21502544
- Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer. N Engl J Med. 2019;381(17):1632-1643. · PubMed 31566309