Atlas One · Host Biology · Scale 07 — System

Colorectal Cancer

Second leading cause of cancer deaths; driven by APC/Wnt loss → adenoma-carcinoma sequence, then KRAS, SMAD4, and TP53 mutations. EGFR blockade (cetuximab) for RAS-wild-type metastatic disease; KRAS/BRAF V600E inhibitors and pembrolizumab (MSI-H) are molecularly targeted.

Also known as: CRC, colon cancer, rectal cancer, colorectal carcinoma, adenocarcinoma of colon, mCRC, Lynch syndrome, FAP

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
colorectal-cancer

Colorectal Cancer

Second leading cause of cancer deaths; driven by APC/Wnt loss → adenoma-carcinoma sequence, then KRAS, SMAD4, and TP53 mutations. EGFR blockade (cetuximab) for RAS-wild-type metastatic disease; KRAS/BRAF V600E inhibitors and pembrolizumab (MSI-H) are molecularly targeted.

Entry Metadata

FieldValue
IDcolorectal-cancer
NameColorectal Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toKras connects-toWnt Beta Catenin connects-toEgfr connects-toBraf connects-toFibronectin connects-toLarge Intestine connects-toLynch Syndrome connects-toP53 connects-toProstate Cancer connects-toLiver connects-toFap

Sources