Atlas One · Host Biology · Scale 07 — System

Endometrial Cancer

Most common gynecologic malignancy in the US (~67,000/year); POLE-ultramutated and MSI-H subtypes respond to pembrolizumab; endometrioid type driven by PTEN/PIK3CA/KRAS; serous by TP53/ERBB2. Carboplatin+paclitaxel is standard; dostarlimab approved for dMMR endometrial cancer.

Also known as: endometrial cancer, endometrial carcinoma, uterine cancer, endometrioid adenocarcinoma, uterine serous carcinoma, POLE-ultramutated, Lynch-associated endometrial cancer

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
endometrial-cancer

Endometrial Cancer

Most common gynecologic malignancy in the US (~67,000/year); POLE-ultramutated and MSI-H subtypes respond to pembrolizumab; endometrioid type driven by PTEN/PIK3CA/KRAS; serous by TP53/ERBB2. Carboplatin+paclitaxel is standard; dostarlimab approved for dMMR endometrial cancer.

Entry Metadata

FieldValue
IDendometrial-cancer
NameEndometrial Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPten connects-toPd 1 connects-toHer2 connects-toMtor connects-toEstrogen connects-toProgesterone connects-toLynch Syndrome connects-toObesity connects-toP53 connects-toBreast Cancer connects-toOvarian Cancer connects-toColorectal Cancer connects-toCowden Syndrome connects-toType 2 Diabetes connects-toT Cytotoxic Cell connects-toPhoton connects-toReproductive System connects-toHlrcc connects-toPik3Ca connects-toInsulin connects-toEndocrine System connects-toLymphatic System connects-toCtnnb1 connects-toLung connects-toMlh1 connects-toFibroblast connects-toVegf connects-toAdipocyte connects-toLiver connects-toMacrophage connects-toIron connects-toNatural Killer Cell connects-toKidney connects-toFibrosis connects-toEndothelial Cell connects-toLarge Intestine connects-toElectron connects-toCalcium connects-toVitamin D connects-toErythrocyte connects-toNeuron connects-toMagnesium connects-toAntibody connects-toNeutrophil connects-toDietary Fiber connects-toIgf 1 connects-toRegulatory T Cell connects-toPeutz Jeghers Syndrome connects-toArid1A connects-toKras connects-toMsh2 connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toAnemia Of Chronic Disease connects-toCkd connects-toMajor Depressive Disorder connects-toOsteoporosis connects-toHeart Failure connects-toAspergillus Fumigatus connects-toWound Healing connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toImmune System connects-toRenal System connects-toCardiovascular System connects-toDigestive System connects-toIntegumentary System connects-toCheckpoint Inhibitors connects-toTargeted Therapy connects-toMetformin connects-toCancer Chemotherapy connects-toCervical Cancer connects-toOvarian Clear Cell Carcinoma connects-toGerminal Center connects-toGastric Cancer connects-toArterial Wall connects-toAlveolus connects-toHepatic Lobule connects-toBladder Cancer connects-toIntestinal Epithelium connects-toLi Fraumeni Syndrome connects-toCovid 19 Disease connects-toAkt connects-toCdk4 6 connects-toHif 1Alpha connects-toMyc connects-toTert connects-toCcl2 connects-toCgas Sting connects-toLeptin connects-toTgf Beta connects-toFgfr connects-toCaspase 3 connects-toCxcl12 connects-toErk1 2 connects-toE2F1 connects-toBcl 2 connects-toIl 6 connects-toMdm2 connects-toWnt Beta Catenin connects-toStat3 connects-toCdkn2A connects-toSmad4 connects-toGalectin 3 connects-toStat1 connects-toEzh2 connects-toFoxo connects-toPerforin connects-toS100A8 A9 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toIl 1B connects-toNotch connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toMhc Class Ii connects-toAdiponectin connects-toAxl Receptor connects-toIl 2 connects-toHemoglobin connects-toCholesterol connects-toProstaglandins connects-toIl 10 connects-toXanthine Oxidase connects-toIl 4 connects-toIron connects-toLung connects-toIl 13 connects-toMacrophage connects-toCowden Syndrome connects-toResistin connects-toType I Interferon connects-toHereditary Breast Ovarian Cancer connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toMast Cell connects-toB Cell connects-toDendritic Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toZinc connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources