Atlas One · Host Biology · Scale 03 — Molecular

CTNNB1

CTNNB1 encodes β-catenin (Wnt effector and adherens junction scaffold); activating mutations (S45F/T41A) → nuclear β-catenin → TCF/LEF target genes (MYC, CCND1, VEGFA); ~80% desmoid tumors harbor CTNNB1 mutations; nirogacestat FDA-approved for desmoid; HCC and endometrial cancer.

Also known as: CTNNB1, beta-catenin, β-catenin, CTNNB1 mutation, Wnt beta-catenin mutation, beta-catenin activating mutation, CTNNB1 desmoid, CTNNB1 colorectal, CTNNB1 hepatocellular, CTNNB1 endometrial

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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ctnnb1

CTNNB1

CTNNB1 encodes β-catenin (Wnt effector and adherens junction scaffold); activating mutations (S45F/T41A) → nuclear β-catenin → TCF/LEF target genes (MYC, CCND1, VEGFA); ~80% desmoid tumors harbor CTNNB1 mutations; nirogacestat FDA-approved for desmoid; HCC and endometrial cancer.

Entry Metadata

FieldValue
IDctnnb1
NameCTNNB1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toWnt Beta Catenin connects-toMyc connects-toNotch connects-toVegf connects-toColorectal Cancer connects-toDesmoid Tumor connects-toHcc

Sources