Atlas One · Host Biology · Scale 07 — System

Desmoid Tumor

Desmoid tumor (aggressive fibromatosis) is a locally invasive spindle cell neoplasm; ~80% harbor CTNNB1 activating mutations; no metastatic potential; nirogacestat (gamma-secretase inhibitor, DeFi trial) FDA-approved 2023; sorafenib active; watch-and-wait for stable disease.

Also known as: desmoid tumor, aggressive fibromatosis, desmoid fibromatosis, deep fibromatosis, desmoid CTNNB1, FAP desmoid, mesenteric fibromatosis, sporadic desmoid, beta-catenin fibromatosis, APC desmoid

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
desmoid-tumor

Desmoid Tumor

Desmoid tumor (aggressive fibromatosis) is a locally invasive spindle cell neoplasm; ~80% harbor CTNNB1 activating mutations; no metastatic potential; nirogacestat (gamma-secretase inhibitor, DeFi trial) FDA-approved 2023; sorafenib active; watch-and-wait for stable disease.

Entry Metadata

FieldValue
IDdesmoid-tumor
NameDesmoid Tumor
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toCtnnb1 connects-toWnt Beta Catenin connects-toNotch connects-toVegf connects-toApc connects-toFap connects-toFibroblast connects-toGist connects-toSmall Intestine connects-toMusculoskeletal System connects-toColorectal Cancer connects-toEstrogen connects-toTgf Beta connects-toSynovial Sarcoma connects-toEwing Sarcoma connects-toReproductive System connects-toCollagen connects-toCyclin D1 connects-toPdgf connects-toPhoton connects-toDigestive System connects-toRhabdomyosarcoma connects-toSmooth Muscle Cell connects-toPlacenta connects-toFibrosis connects-toMtor connects-toMast Cell connects-toMacrophage connects-toAkt connects-toT Cytotoxic Cell connects-toOxygen connects-toLarge Intestine connects-toKidney connects-toFibronectin connects-toEndothelial Cell connects-toPeripheral Nerve connects-toSkin connects-toElectron connects-toLung connects-toBone Marrow connects-toNeuron connects-toStomach connects-toAdipocyte connects-toProgesterone connects-toOsteoblast connects-toPancreas connects-toBreast Cancer connects-toRegulatory T Cell connects-toIl 6 connects-toWound Healing connects-toYap1 connects-toGastric Cancer connects-toStat3 connects-toCkd connects-toVenous Thromboembolism connects-toNeuropathic Pain connects-toSepsis connects-toMajor Depressive Disorder connects-toHeart Failure connects-toAnemia Of Chronic Disease connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toRenal System connects-toIntegumentary System connects-toCardiovascular System connects-toNervous System connects-toLymphatic System connects-toRespiratory System connects-toIbuprofen connects-toImmune System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toThyroid Cancer connects-toIntestinal Epithelium connects-toCortical Bone connects-toSystemic Sclerosis connects-toMedulloblastoma connects-toArterial Wall connects-toGlomerulus connects-toMutyh Associated Polyposis connects-toHcc connects-toMpnst connects-toProstaglandins connects-toKit connects-toTert connects-toMyc connects-toCdk4 6 connects-toHif 1Alpha connects-toIgf 1 connects-toErk1 2 connects-toCcl2 connects-toGsk 3B connects-toCaspase 3 connects-toFgfr connects-toPeriostin connects-toGalectin 3 connects-toSmad4 connects-toPik3Ca connects-toE2F1 connects-toPten connects-toJak1 2 connects-toBcl 2 connects-toKras connects-toCdkn2A connects-toNf Kb connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toEzh2 connects-toSrc Kinase connects-toS100A8 A9 connects-toPerforin connects-toMdm2 connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toAndrogen Receptor connects-toAxl Receptor connects-toMhc Class Ii connects-toIl 2 connects-toIl 10 connects-toNitric Oxide connects-toFap connects-toXanthine Oxidase connects-toIl 4 connects-toIl 13 connects-toMacrophage connects-toLarge Intestine connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNatural Killer Cell connects-toNeutrophil connects-toOsteosarcoma connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toDendritic Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toOsteopontin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toCarbon connects-toChloride connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toCortisol

Sources