Atlas One · Host Biology · Scale 07 — System

Familial Adenomatous Polyposis

Familial adenomatous polyposis (FAP) is caused by germline APC mutations; >100 colorectal adenomas from age 10-20; CRC by 30-40 without treatment; prophylactic proctocolectomy is curative; desmoid tumor, duodenal adenomas, and Gardner syndrome are extracolonic features.

Also known as: FAP, familial adenomatous polyposis, APC polyposis, Gardner syndrome, attenuated FAP, AFAP, FAP colon, hereditary CRC APC, APC syndrome, FAP desmoid

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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fap

Familial Adenomatous Polyposis

Familial adenomatous polyposis (FAP) is caused by germline APC mutations; >100 colorectal adenomas from age 10-20; CRC by 30-40 without treatment; prophylactic proctocolectomy is curative; desmoid tumor, duodenal adenomas, and Gardner syndrome are extracolonic features.

Entry Metadata

FieldValue
IDfap
NameFamilial Adenomatous Polyposis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toApc connects-toCtnnb1 connects-toColorectal Cancer connects-toDesmoid Tumor connects-toMutyh Associated Polyposis connects-toKras connects-toLarge Intestine connects-toHereditary Diffuse Gastric Cancer connects-toSmall Intestine connects-toThyroid Cancer connects-toJuvenile Polyposis Syndrome connects-toGastric Cancer connects-toIntestinal Epithelium

Sources