Atlas One · Host Biology · Scale 07 — System

Familial Adenomatous Polyposis

Familial adenomatous polyposis (FAP) is caused by germline APC mutations; >100 colorectal adenomas from age 10-20; CRC by 30-40 without treatment; prophylactic proctocolectomy is curative; desmoid tumor, duodenal adenomas, and Gardner syndrome are extracolonic features.

Also known as: FAP, familial adenomatous polyposis, APC polyposis, Gardner syndrome, attenuated FAP, AFAP, FAP colon, hereditary CRC APC, APC syndrome, FAP desmoid

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
fap

Familial Adenomatous Polyposis

Familial adenomatous polyposis (FAP) is caused by germline APC mutations; >100 colorectal adenomas from age 10-20; CRC by 30-40 without treatment; prophylactic proctocolectomy is curative; desmoid tumor, duodenal adenomas, and Gardner syndrome are extracolonic features.

Entry Metadata

FieldValue
IDfap
NameFamilial Adenomatous Polyposis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toApc connects-toCtnnb1 connects-toColorectal Cancer connects-toDesmoid Tumor connects-toMutyh Associated Polyposis connects-toKras connects-toLarge Intestine connects-toHereditary Diffuse Gastric Cancer connects-toSmall Intestine connects-toThyroid Cancer connects-toJuvenile Polyposis Syndrome connects-toGastric Cancer connects-toIntestinal Epithelium connects-toLynch Syndrome connects-toPeutz Jeghers Syndrome connects-toMedulloblastoma connects-toWnt Beta Catenin connects-toStomach connects-toPancreatic Cancer connects-toDigestive System connects-toEye connects-toIntegumentary System connects-toLiver connects-toBrain connects-toFibroblast connects-toOsteoblast connects-toMyc connects-toImmune System connects-toSkin connects-toVegf connects-toMacrophage connects-toIron connects-toPancreas connects-toEndothelial Cell connects-toPhoton connects-toFibrosis connects-toThyroid connects-toElectron connects-toBone Marrow connects-toCalcium connects-toMusculoskeletal System connects-toNeuron connects-toAdrenal Gland connects-toCyclin D1 connects-toHepatocyte connects-toPlatelet connects-toP53 connects-toRegulatory T Cell connects-toCowden Syndrome connects-toIron Deficiency Anemia connects-toVenous Thromboembolism connects-toSepsis connects-toNf Kb connects-toStat3 connects-toAnemia Of Chronic Disease connects-toCkd connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toEndocrine System connects-toNervous System connects-toGut Microbiome connects-toReproductive System connects-toRenal System connects-toCardiovascular System connects-toIbuprofen connects-toLymphatic System connects-toDietary Fiber connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toEscherichia Coli connects-toCortical Bone connects-toHepatic Lobule connects-toAspirin connects-toGorlin Syndrome connects-toNeuroendocrine Tumors connects-toLi Fraumeni Syndrome connects-toCholangiocarcinoma connects-toHcc connects-toBladder Cancer connects-toProstaglandins connects-toTgf Beta connects-toMtor connects-toAkt connects-toEzh2 connects-toHif 1Alpha connects-toTert connects-toPdgf connects-toSmad4 connects-toGsk 3B connects-toNotch connects-toCaspase 3 connects-toMutyh connects-toMlh1 connects-toFgfr connects-toEgfr connects-toErk1 2 connects-toPik3Ca connects-toPten connects-toMyd88 connects-toIl 6 connects-toGalectin 3 connects-toCdkn2A connects-toCgas Sting connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toPerforin connects-toS100A8 A9 connects-toMdm2 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toRankl connects-toEstrogen connects-toMhc Class Ii connects-toHemoglobin connects-toT Cytotoxic Cell connects-toXanthine Oxidase connects-toIl 10 connects-toLeptin connects-toCholesterol connects-toIl 4 connects-toIl 13 connects-toOmega 3 Fatty Acids connects-toAdiponectin connects-toResistin connects-toHepcidin connects-toObesity connects-toType I Interferon connects-toDendritic Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toIl 2 connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine