Atlas One · Host Biology · Scale 03 — Molecular

Xanthine Oxidase

Xanthine oxidase (XOR/XDH) catalyzes hypoxanthine → xanthine → uric acid, generating reactive oxygen species; hyperuricemia → MSU crystal deposition → NLRP3-driven gouty arthritis; allopurinol and febuxostat inhibit XOR to reduce uric acid in gout and chronic hyperuricemia.

Also known as: xanthine oxidase, XOR, XDH, xanthine dehydrogenase, xanthine oxidoreductase, XO, uric acid enzyme, allopurinol target, febuxostat target, purine catabolism

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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xanthine-oxidase

Xanthine Oxidase

Xanthine oxidase (XOR/XDH) catalyzes hypoxanthine → xanthine → uric acid, generating reactive oxygen species; hyperuricemia → MSU crystal deposition → NLRP3-driven gouty arthritis; allopurinol and febuxostat inhibit XOR to reduce uric acid in gout and chronic hyperuricemia.

Entry Metadata

FieldValue
IDxanthine-oxidase
NameXanthine Oxidase
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toGout connects-toNlrp3 Inflammasome connects-toCardiovascular System connects-toCkd connects-toNitric Oxide connects-toIl 1B connects-toAldosterone

Sources