Atlas One · Host Biology · Scale 07 — System

MUTYH-Associated Polyposis

MUTYH-associated polyposis (MAP) is an autosomal recessive CRC predisposition syndrome caused by biallelic MUTYH mutations; 10-100 colorectal adenomas; CRC risk ~40-75% lifetime; two founder variants (Y179C, G396D) in most Western patients; annual colonoscopy from age 25.

Also known as: MAP, MUTYH-associated polyposis, MYH-associated polyposis, biallelic MUTYH, MUTYH polyposis, MAP CRC, MYH polyposis, autosomal recessive polyposis, MAP colorectal

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
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mutyh-associated-polyposis

MUTYH-Associated Polyposis

MUTYH-associated polyposis (MAP) is an autosomal recessive CRC predisposition syndrome caused by biallelic MUTYH mutations; 10-100 colorectal adenomas; CRC risk ~40-75% lifetime; two founder variants (Y179C, G396D) in most Western patients; annual colonoscopy from age 25.

Entry Metadata

FieldValue
IDmutyh-associated-polyposis
NameMUTYH-Associated Polyposis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMutyh connects-toApc connects-toColorectal Cancer connects-toFap connects-toKras connects-toWnt Beta Catenin connects-toLynch Syndrome connects-toHlrcc connects-toLarge Intestine connects-toSmall Intestine

Sources