Atlas One · Host Biology · Scale 07 — System

MUTYH-Associated Polyposis

MUTYH-associated polyposis (MAP) is an autosomal recessive CRC predisposition syndrome caused by biallelic MUTYH mutations; 10-100 colorectal adenomas; CRC risk ~40-75% lifetime; two founder variants (Y179C, G396D) in most Western patients; annual colonoscopy from age 25.

Also known as: MAP, MUTYH-associated polyposis, MYH-associated polyposis, biallelic MUTYH, MUTYH polyposis, MAP CRC, MYH polyposis, autosomal recessive polyposis, MAP colorectal

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
mutyh-associated-polyposis

MUTYH-Associated Polyposis

MUTYH-associated polyposis (MAP) is an autosomal recessive CRC predisposition syndrome caused by biallelic MUTYH mutations; 10-100 colorectal adenomas; CRC risk ~40-75% lifetime; two founder variants (Y179C, G396D) in most Western patients; annual colonoscopy from age 25.

Entry Metadata

FieldValue
IDmutyh-associated-polyposis
NameMUTYH-Associated Polyposis
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toMutyh connects-toApc connects-toColorectal Cancer connects-toFap connects-toKras connects-toWnt Beta Catenin connects-toLynch Syndrome connects-toHlrcc connects-toLarge Intestine connects-toSmall Intestine connects-toJuvenile Polyposis Syndrome connects-toPeutz Jeghers Syndrome connects-toGastric Cancer connects-toHereditary Diffuse Gastric Cancer connects-toPancreatic Cancer connects-toEndometrial Cancer connects-toIntestinal Epithelium connects-toStomach connects-toP53 connects-toDigestive System connects-toOxygen connects-toBladder Cancer connects-toT Cytotoxic Cell connects-toOvarian Cancer connects-toBreast Cancer connects-toCdkn2A connects-toNatural Killer Cell connects-toDendritic Cell connects-toLiver connects-toNf Kb connects-toRegulatory T Cell connects-toIron connects-toMacrophage connects-toFibrosis connects-toPhoton connects-toThyroid connects-toSkin connects-toElectron connects-toBone Marrow connects-toEye connects-toAntibody connects-toErythrocyte connects-toDietary Fiber connects-toReproductive System connects-toPlatelet connects-toPlasma Cell connects-toMsh2 connects-toCowden Syndrome connects-toHereditary Breast Ovarian Cancer connects-toIron Deficiency Anemia connects-toVenous Thromboembolism connects-toSepsis connects-toStat3 connects-toCyclin D1 connects-toAnemia Of Chronic Disease connects-toCkd connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toGeneralized Anxiety Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toGut Microbiome connects-toEndocrine System connects-toIntegumentary System connects-toMusculoskeletal System connects-toImmune System connects-toLymphatic System connects-toAspirin connects-toRenal System connects-toRespiratory System connects-toCancer Chemotherapy connects-toEscherichia Coli connects-toCheckpoint Inhibitors connects-toNfe2L2 connects-toAml connects-toDesmoid Tumor connects-toBloom Syndrome connects-toGerminal Center connects-toCortical Bone connects-toWerner Syndrome connects-toMds connects-toBrca2 connects-toMyc connects-toEgfr connects-toTert connects-toAkt connects-toCdk4 6 connects-toHif 1Alpha connects-toSmad4 connects-toBraf connects-toCcl2 connects-toGsk 3B connects-toNotch connects-toCaspase 3 connects-toXanthine Oxidase connects-toProstaglandins connects-toMlh1 connects-toErk1 2 connects-toPik3Ca connects-toE2F1 connects-toPten connects-toMyd88 connects-toIl 6 connects-toGalectin 3 connects-toJak1 2 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toPerforin connects-toMdm2 connects-toS100A8 A9 connects-toEzh2 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toHemoglobin connects-toMhc Class Ii connects-toPd 1 connects-toIl 2 connects-toIl 10 connects-toT Helper Cell connects-toCholesterol connects-toIl 4 connects-toLeptin connects-toIl 13 connects-toAdiponectin connects-toCalcium connects-toResistin connects-toHepcidin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toFibroblast connects-toMast Cell connects-toVitamin D connects-toSelenium connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toTslp connects-toErythropoietin connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toChloride connects-toPhosphorus connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toVegf connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin

Sources