Atlas One · Host Biology · Scale 03 — Molecular

Periostin

Periostin (POSTN, chr13q13.3) is an ECM matricellular protein induced by IL-4/IL-13 → STAT6 and TGF-β → SMAD3; serum periostin >25 ng/mL predicts T2-high asthma biologic response; periostin drives cardiac and renal fibrosis via integrin αvβ3/αvβ5 → FAK/PI3K.

Also known as: periostin, POSTN, osteoblast-specific factor 2, OSF-2, OSF2, PDLP

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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periostin

Periostin

Periostin (POSTN, chr13q13.3) is an ECM matricellular protein induced by IL-4/IL-13 → STAT6 and TGF-β → SMAD3; serum periostin >25 ng/mL predicts T2-high asthma biologic response; periostin drives cardiac and renal fibrosis via integrin αvβ3/αvβ5 → FAK/PI3K.

Entry Metadata

FieldValue
IDperiostin
NamePeriostin
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAsthma connects-toHeart Failure connects-toTgf Beta connects-toAtopic Dermatitis connects-toNash connects-toLung

Sources