Atlas One · Host Biology · Scale 02 — Atomic

Calcium

Ca²⁺ — the preeminent intracellular second messenger. In the heart, a 10-fold cytosolic Ca²⁺ transient (100 nM → 1 µM during systole) triggers troponin C and every contraction via CICR from the SR. β1-AR/PKA signaling and SERCA2a tune the Ca²⁺ transient.

Also known as: Ca, Ca²⁺, calcium ion, calcium signaling

Scale 02 — AtomicScale
draftStatus
2026-06-03Last Reviewed
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calcium

Calcium

Ca²⁺ — the preeminent intracellular second messenger. In the heart, a 10-fold cytosolic Ca²⁺ transient (100 nM → 1 µM during systole) triggers troponin C and every contraction via CICR from the SR. β1-AR/PKA signaling and SERCA2a tune the Ca²⁺ transient.

Entry Metadata

FieldValue
IDcalcium
NameCalcium
Statusdraft
Last reviewed2026-06-03
Atlas01-human
Scale02-atomic

Cross-Atlas Connections

modulatesTroponin Complex modulatesCardiomyocyte modulatesBeta1 Adrenergic Receptor modulated-byElectron modulated-byRyr2 modulated-bySerca2A modulated-byNcx1 modulated-byCalcium Channel Blockers

Sources