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ncx1
NCX1 (Na⁺/Ca²⁺ exchanger 1)
NCX1 (SLC8A1) — cardiac sarcolemmal Na⁺/Ca²⁺ exchanger. Electrogenic: exchanges 3 Na⁺ for 1 Ca²⁺, generating net current. Forward mode (Ca²⁺ extrusion) removes ~28% of Ca²⁺ after systole; reverse mode contributes to CICR in SA node. Upregulated in heart failure.
Entry Metadata
| Field | Value |
|---|---|
| ID | ncx1 |
| Name | NCX1 (Na⁺/Ca²⁺ exchanger 1) |
| Status | draft |
| Last reviewed | 2026-06-03 |
| Atlas | 01-human |
| Scale | 03-molecular |
| Uniprot | P32418 |
| Gene Symbol | SLC8A1 |
| Chromosome | 2p22.1 |
Cross-Atlas Connections
Sources
- Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev. 1999;79(3):763-854. · PubMed 10390518
- Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415(6868):198-205. · PubMed 11805843
- Philipson KD, Bhargava P. Molecular studies of Na+/Ca2+ exchangers. Basic Res Cardiol. 2002;97 Suppl 1:I15-I20. · PubMed 12479234
- Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res. 2003;93(1):46-53. · PubMed 12791707