Atlas One · Host Biology · Scale 03 — Molecular

STAT1

STAT1 transduces type I IFN (IFNAR → JAK1/TYK2 → STAT1/STAT2/IRF9 → ISGF3 → ISGs) and IFN-γ (IFNGR → JAK1/JAK2 → STAT1 homodimer → GAS → IRF1 → iNOS); STAT1 GOF mutations → chronic mucocutaneous candidiasis (CMC); STAT1 LOF → MSMD and viral susceptibility.

Also known as: STAT1, signal transducer and activator of transcription 1, ISGF3, GAF, GAS element, ISRE, JAK-STAT signaling, interferon signaling, ISG induction, MSMD-STAT1, CMC-STAT1

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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stat1

STAT1

STAT1 transduces type I IFN (IFNAR → JAK1/TYK2 → STAT1/STAT2/IRF9 → ISGF3 → ISGs) and IFN-γ (IFNGR → JAK1/JAK2 → STAT1 homodimer → GAS → IRF1 → iNOS); STAT1 GOF mutations → chronic mucocutaneous candidiasis (CMC); STAT1 LOF → MSMD and viral susceptibility.

Entry Metadata

FieldValue
IDstat1
NameSTAT1
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toType I Interferon connects-toIfn Gamma connects-toDengue Fever connects-toTuberculosis connects-toInfluenza

Sources