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ifn-gamma
IFN-gamma
Primary Th1 cytokine produced by CD4+ Th1, CD8+ CTLs, and NK cells; binds IFNGR1/2 → JAK1/2 → STAT1 → MHC-II, IDO1, and antimicrobial gene induction. Central mediator of adaptive cellular immunity and antitumor immunosurveillance; evaded by PD-L1 upregulation in tumors.
Entry Metadata
| Field | Value |
|---|---|
| ID | ifn-gamma |
| Name | IFN-gamma |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004;75(2):163-189. · PubMed 14525967
- Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005;5(5):375-386. · PubMed 15864272
- Pitt JM, Vétizou M, Daillère R, et al. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity. 2016;44(6):1255-1269. · PubMed 27332732