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hepcidin
Hepcidin
Hepcidin (HAMP; chr19q13.12) is the master iron regulatory hormone produced by hepatocytes; binds ferroportin → internalization → blocks iron efflux from enterocytes, macrophages, and hepatocytes. IL-6→STAT3→hepcidin drives anemia of chronic disease; inhibitors under development.
Entry Metadata
| Field | Value |
|---|---|
| ID | hepcidin |
| Name | Hepcidin |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. · PubMed 15514116
- Ganz T. Systemic iron homeostasis. Physiol Rev. 2013;93(4):1721-1741. · PubMed 24137020
- Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832-1843. · PubMed 25946282