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caspase-3
Caspase-3
Executioner caspase of apoptosis; cleaves PARP, lamins, and hundreds of substrates → orderly cell dismantling. Activated by intrinsic (cytochrome c → caspase-9) and extrinsic (FasL → caspase-8) pathways; BCL-2 and IAPs suppress caspase-3 to evade apoptosis in cancer.
Entry Metadata
| Field | Value |
|---|---|
| ID | caspase-3 |
| Name | Caspase-3 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Nicholson DW, Thornberry NA. Caspases: killer proteases. Trends Biochem Sci. 1997;22(8):299-306. · PubMed 9270303
- Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 2008;9(3):231-241. · PubMed 18073771
- Porter AG, Jänicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999;6(2):99-104. · PubMed 10200555