Atlas One · Host Biology · Scale 07 — System

CLL

Most common adult leukemia; clonal CD5+/CD19+/CD23+ B-cell malignancy; del(17p)/TP53 mutation is highest-risk. Ibrutinib and venetoclax transformed CLL; obinutuzumab+venetoclax is first-line for unfit patients; pirtobrutinib is active in covalent BTK-inhibitor-resistant CLL.

Also known as: CLL, chronic lymphocytic leukemia, small lymphocytic lymphoma, SLL, B-CLL, CLL/SLL, del(17p) CLL, del(11q) CLL

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cll

CLL

Most common adult leukemia; clonal CD5+/CD19+/CD23+ B-cell malignancy; del(17p)/TP53 mutation is highest-risk. Ibrutinib and venetoclax transformed CLL; obinutuzumab+venetoclax is first-line for unfit patients; pirtobrutinib is active in covalent BTK-inhibitor-resistant CLL.

Entry Metadata

FieldValue
IDcll
NameCLL
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toBcl 2 connects-toP53 connects-toNf Kb connects-toAtm connects-toBtk connects-toB Cell connects-toCd20 connects-toBone Marrow connects-toSpleen connects-toDlbcl connects-toLymphatic System connects-toMantle Cell Lymphoma connects-toImmune System connects-toCml connects-toFollicular Lymphoma connects-toT Cytotoxic Cell connects-toPlasma Cell connects-toImmunoglobulin G connects-toNatural Killer Cell connects-toErythrocyte connects-toPd 1 connects-toImmune Thrombocytopenia connects-toHeart connects-toRegulatory T Cell connects-toHodgkin Lymphoma connects-toMacrophage connects-toIl 4 connects-toVegf connects-toCalcium connects-toLiver connects-toDendritic Cell connects-toSkin connects-toNeutrophil connects-toIl 10 connects-toPhoton connects-toPotassium connects-toGerminal Center connects-toElectron connects-toLung connects-toPhosphorus connects-toAntibody connects-toPlatelet connects-toKidney connects-toStreptococcus Pneumoniae connects-toNotch connects-toMelanoma connects-toBaff connects-toBasal Cell Carcinoma connects-toT Helper Cell connects-toCxcl12 connects-toPneumocystis Jirovecii connects-toStroke connects-toStat3 connects-toSepsis connects-toVenous Thromboembolism connects-toAspergillus Fumigatus connects-toHepatitis B Virus connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toVaricella Zoster Virus connects-toMajor Depressive Disorder connects-toCardiovascular System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toRenal System connects-toDigestive System connects-toMusculoskeletal System connects-toNervous System connects-toEndocrine System connects-toTargeted Therapy connects-toWaldenstrom Macroglobulinemia connects-toEpstein Barr Virus connects-toCancer Chemotherapy connects-toCar T connects-toAml connects-toBurkitt Lymphoma connects-toMultiple Myeloma connects-toHepatic Lobule connects-toCovid 19 Disease connects-toCardiac Conduction System connects-toNsclc connects-toMds connects-toAkt connects-toCyclin D1 connects-toEzh2 connects-toIl 6 connects-toTnf Alpha connects-toPik3Ca connects-toMyc connects-toCcl2 connects-toSf3B1 connects-toSrc Kinase connects-toTert connects-toComplement C3 connects-toPerforin connects-toFoxo connects-toPten connects-toErk1 2 connects-toCdkn2A connects-toMyd88 connects-toJak1 2 connects-toMtor connects-toTgf Beta connects-toGalectin 3 connects-toCgas Sting connects-toStat1 connects-toSmad4 connects-toCdk4 6 connects-toGsk 3B connects-toS100A8 A9 connects-toMdm2 connects-toHif 1Alpha connects-toAutophagy connects-toDnmt3A connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toHemoglobin connects-toIl 2 connects-toTroponin Complex connects-toXanthine Oxidase connects-toSecretory Iga connects-toIron connects-toIl 13 connects-toProstaglandins connects-toHepcidin connects-toLeptin connects-toAdiponectin connects-toResistin connects-toRegulatory T Cell connects-toIron connects-toRegulatory T Cell connects-toNatural Killer Cell connects-toWaldenstrom Macroglobulinemia connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toMast Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources