Atlas One · Host Biology · Scale 03 — Molecular

BAFF

BAFF (BLyS; TNFSF13B; chr13q34) is a TNF-family B-cell survival cytokine; signals via BAFF-R (non-canonical NF-κB2/RelB), TACI, and BCMA. Belimumab (anti-BAFF; FDA Mar 2011) is approved for SLE; ianalumab (anti-BAFFR) met Phase 3 endpoint in Sjögren's (TWINSS 2023).

Also known as: BAFF, BLyS, B-cell activating factor, TNFSF13B, B lymphocyte stimulator, CD257, TALL-1, THANK, belimumab target

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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baff

BAFF

BAFF (BLyS; TNFSF13B; chr13q34) is a TNF-family B-cell survival cytokine; signals via BAFF-R (non-canonical NF-κB2/RelB), TACI, and BCMA. Belimumab (anti-BAFF; FDA Mar 2011) is approved for SLE; ianalumab (anti-BAFFR) met Phase 3 endpoint in Sjögren's (TWINSS 2023).

Entry Metadata

FieldValue
IDbaff
NameBAFF
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toNf Kb connects-toSystemic Lupus Erythematosus connects-toSjogrens Syndrome connects-toPlasma Cell

Sources