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nsclc
NSCLC
Most common lung cancer subtype (~85%); adenocarcinoma (KRAS/EGFR/ALK drivers), squamous cell carcinoma, and large cell. EGFR TKIs (osimertinib) and ALK inhibitors (alectinib) are highly active; pembrolizumab + chemotherapy transforms KRAS/squamous disease.
Entry Metadata
| Field | Value |
|---|---|
| ID | nsclc |
| Name | NSCLC |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toKras
connects-toEgfr
connects-toBraf
connects-toPd 1
connects-toLung
connects-toAlk
connects-toType Ii Pneumocyte
connects-toMelanoma
connects-toT Cytotoxic Cell
connects-toSclc
connects-toMesothelioma
connects-toPhoton
connects-toMacrophage
connects-toBrain
connects-toCarbon
connects-toHnscc
connects-toMet
connects-toAdrenal Gland
connects-toCopd
connects-toP53
connects-toRespiratory System
connects-toLymphatic System
connects-toLiver
connects-toCtla 4
connects-toRet
connects-toNfe2L2
connects-toRegulatory T Cell
connects-toFibroblast
connects-toOxygen
connects-toVegf
connects-toDendritic Cell
connects-toCalcium
connects-toHeart
connects-toFibrosis
connects-toElectron
connects-toBone Marrow
connects-toPlatelet
connects-toStk11
connects-toOsteoclast
connects-toNeutrophil
connects-toAntibody
connects-toKidney
connects-toMagnesium
connects-toVenous Thromboembolism
connects-toThyroid
connects-toCardiomyocyte
connects-toHer2
connects-toTert
connects-toAlveolus
connects-toCdkn2A
connects-toSepsis
connects-toStroke
connects-toNf Kb
connects-toStat3
connects-toAnemia Of Chronic Disease
connects-toHeart Failure
connects-toMajor Depressive Disorder
connects-toAspergillus Fumigatus
connects-toStreptococcus Pneumoniae
connects-toCkd
connects-toGeneralized Anxiety Disorder
connects-toNervous System
connects-toEndocrine System
connects-toMusculoskeletal System
connects-toImmune System
connects-toIntegumentary System
connects-toCardiovascular System
connects-toTargeted Therapy
connects-toDigestive System
connects-toRenal System
connects-toCheckpoint Inhibitors
connects-toCancer Chemotherapy
connects-toCortical Bone
connects-toGerminal Center
connects-toThyroid Cancer
connects-toBladder Cancer
connects-toHepatic Lobule
connects-toPancreatic Cancer
connects-toMyocardium
connects-toNeuroblastoma
connects-toEpilepsy
connects-toTuberculosis
connects-toNtrk
connects-toPik3Ca
connects-toMyc
connects-toAkt
connects-toCyclin D1
connects-toHif 1Alpha
connects-toCcl2
connects-toTgf Beta
connects-toCgas Sting
connects-toFgfr
connects-toCxcl12
connects-toJak1 2
connects-toPten
connects-toAxl Receptor
connects-toCdk4 6
connects-toErk1 2
connects-toMtor
connects-toE2F1
connects-toRb1
connects-toIl 6
connects-toMyd88
connects-toGalectin 3
connects-toAmpk
connects-toSmad4
connects-toStat1
connects-toFoxo
connects-toEzh2
connects-toPerforin
connects-toMdm2
connects-toS100A8 A9
connects-toGsk 3B
connects-toSrc Kinase
connects-toDnmt3A
connects-toAutophagy
connects-toCcr5
connects-toArid1A
connects-toIl 1B
connects-toIl 33
connects-toIl 17A
connects-toRankl
connects-toMhc Class Ii
connects-toCaspase 3
connects-toIl 2
connects-toTroponin Complex
connects-toPth
connects-toHemoglobin
connects-toXanthine Oxidase
connects-toMu Opioid Receptor
connects-toProstaglandins
connects-toLiver
connects-toCalcium
connects-toIl 4
connects-toAdrenal Gland
connects-toPhoton
connects-toIl 13
connects-toLeptin
connects-toAdiponectin
connects-toResistin
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toNatural Killer Cell
connects-toB Cell
connects-toT Helper Cell
connects-toComplement C3
connects-toTslp
connects-toPeriostin
connects-toHistamine
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toMelatonin
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toCopper
connects-toZinc
connects-toPotassium
connects-toChloride
connects-toHydrogen
connects-toNitrogen
connects-toIron
connects-toPhosphorus
connects-toSulfur
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toEpinephrine
Sources
- Soria JC, Ohe Y, Vansteenkiste J, et al. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. N Engl J Med. 2018;378(2):113-125. · PubMed 29151359
- Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med. 2016;375(19):1823-1833. · PubMed 27718347
- Riely GJ, Ou SHI, Rybkin I, et al. KRYSTAL-1: activity and preliminary pharmacodynamic (PD) analysis of adagrasib (MRTX849) in patients (Pts) with advanced/metastatic non-small cell lung cancer (NSCLC) harboring KRASG12C mutation. J Thorac Oncol. 2022;17(10):1248-1258. · PubMed 35817313