Atlas One · Host Biology · Scale 03 — Molecular

Mu-Opioid Receptor

μ-opioid receptor (MOR/OPRM1), Gi-coupled GPCR activated by β-endorphin and opioid drugs; mediates analgesia via PAG descending pathway, euphoria via VTA disinhibition → NAcc dopamine, and respiratory depression via pre-Bötzinger complex; therapeutic target for pain and OUD.

Also known as: mu-opioid receptor, MOR, OPRM1, μ-opioid receptor, mu opioid, beta-endorphin receptor, morphine receptor, opioid receptor mu, A118G, Asn40Asp

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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mu-opioid-receptor

Mu-Opioid Receptor

μ-opioid receptor (MOR/OPRM1), Gi-coupled GPCR activated by β-endorphin and opioid drugs; mediates analgesia via PAG descending pathway, euphoria via VTA disinhibition → NAcc dopamine, and respiratory depression via pre-Bötzinger complex; therapeutic target for pain and OUD.

Entry Metadata

FieldValue
IDmu-opioid-receptor
NameMu-Opioid Receptor
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toDopamine connects-toGaba connects-toNorepinephrine connects-toBdnf connects-toBrain connects-toAlcohol Use Disorder connects-toOpioid Use Disorder connects-toGambling Disorder

Sources