Atlas One · Host Biology · Scale 07 — System

Opioid Use Disorder

Opioid use disorder (~2.7M US; ~80K deaths/year fentanyl) involves μ-opioid-mediated VTA disinhibition → NAcc dopamine surge, tolerance, and LC rebound withdrawal; MOUD: buprenorphine, methadone, naltrexone; naloxone reverses overdose.

Also known as: opioid use disorder, OUD, heroin addiction, opioid dependence, buprenorphine, methadone, naltrexone, Suboxone, MOUD, COWS, opioid overdose, naloxone, fentanyl

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
opioid-use-disorder

Opioid Use Disorder

Opioid use disorder (~2.7M US; ~80K deaths/year fentanyl) involves μ-opioid-mediated VTA disinhibition → NAcc dopamine surge, tolerance, and LC rebound withdrawal; MOUD: buprenorphine, methadone, naltrexone; naloxone reverses overdose.

Entry Metadata

FieldValue
IDopioid-use-disorder
NameOpioid Use Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDopamine connects-toGaba connects-toGlutamate connects-toBdnf connects-toNorepinephrine targetsBrain connects-toMu Opioid Receptor connects-toHeart connects-toStimulant Use Disorder connects-toHepatitis C connects-toHiv Aids connects-toAlcohol Use Disorder connects-toGambling Disorder connects-toNeuropathic Pain connects-toNeuron connects-toRespiratory System connects-toMajor Depressive Disorder connects-toLung connects-toEndocannabinoid connects-toPtsd connects-toNervous System connects-toPlacenta connects-toStaphylococcus Aureus connects-toDigestive System connects-toCarbon connects-toLiver connects-toInsomnia Disorder connects-toOxygen connects-toSynapse connects-toMicroglia connects-toLarge Intestine connects-toHydrogen connects-toAstrocyte connects-toPhoton connects-toEndothelial Cell connects-toSkin connects-toKidney connects-toPeripheral Nerve connects-toPlatelet connects-toEye connects-toTestosterone connects-toStomach connects-toReproductive System connects-toAntibody connects-toGut Microbiome connects-toHiv connects-toOrexin connects-toAdrenal Gland connects-toNlrp3 Inflammasome connects-toMast Cell connects-toOsteoporosis connects-toNf Kb connects-toSepsis connects-toCandida Albicans connects-toVenous Thromboembolism connects-toCkd connects-toGeneralized Anxiety Disorder connects-toWound Healing connects-toHeart Failure connects-toPulmonary Arterial Hypertension connects-toIntegumentary System connects-toEndocrine System connects-toMusculoskeletal System connects-toCardiovascular System connects-toImmune System connects-toLymphatic System connects-toRenal System connects-toHepatitis B Virus connects-toClostridium Tetani connects-toHepatitis C Virus connects-toCrh connects-toBinge Eating Disorder connects-toEndocardium connects-toCannabis Use Disorder connects-toAlveolus connects-toCardiac Conduction System connects-toIntestinal Epithelium connects-toBipolar Disorder connects-toHepatitis B connects-toCortical Bone connects-toCovid 19 Disease connects-toTuberculosis connects-toGlomerulus connects-toStroke connects-toTnf Alpha connects-toIl 6 connects-toCortisol connects-toTlr4 connects-toSerotonin connects-toHistamine connects-toCcl2 connects-toGsk 3B connects-toNpy connects-toOxytocin connects-toProlactin connects-toGhrelin connects-toErk1 2 connects-toAkt connects-toGlucocorticoid Receptor connects-toMyd88 connects-toMtor connects-toNtrk connects-toPten connects-toGalectin 3 connects-toJak1 2 connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toPik3Ca connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toAdenosine connects-toNitric Oxide connects-toEstrogen connects-toMelatonin connects-toProton connects-toIl 10 connects-toProgesterone connects-toProstaglandins connects-toXanthine Oxidase connects-toGlp 1 connects-toIl 4 connects-toMagnesium connects-toZinc connects-toIl 13 connects-toHeart connects-toHepatitis C connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toPeriostin connects-toTransferrin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toIron connects-toChloride connects-toNitrogen connects-toSulfur connects-toPd 1 connects-toAngiotensin Ii connects-toVegf connects-toWnt Beta Catenin connects-toGlp 1 connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr

Sources