Atlas One · Host Biology · Scale 07 — System

Opioid Use Disorder

Opioid use disorder (~2.7M US; ~80K deaths/year fentanyl) involves μ-opioid-mediated VTA disinhibition → NAcc dopamine surge, tolerance, and LC rebound withdrawal; MOUD: buprenorphine, methadone, naltrexone; naloxone reverses overdose.

Also known as: opioid use disorder, OUD, heroin addiction, opioid dependence, buprenorphine, methadone, naltrexone, Suboxone, MOUD, COWS, opioid overdose, naloxone, fentanyl

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
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opioid-use-disorder

Opioid Use Disorder

Opioid use disorder (~2.7M US; ~80K deaths/year fentanyl) involves μ-opioid-mediated VTA disinhibition → NAcc dopamine surge, tolerance, and LC rebound withdrawal; MOUD: buprenorphine, methadone, naltrexone; naloxone reverses overdose.

Entry Metadata

FieldValue
IDopioid-use-disorder
NameOpioid Use Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toDopamine connects-toGaba connects-toGlutamate connects-toBdnf connects-toNorepinephrine targetsBrain

Sources