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clostridium-tetani
Clostridium tetani
Anaerobic, spore-forming, Gram-positive rod. Produces tetanospasmin (TeNT), a zinc-metalloprotease that cleaves VAMP-2 in inhibitory interneurons, blocking GABA/glycine release causing spastic paralysis. 100% preventable by tetanus toxoid vaccination.
Entry Metadata
| Field | Value |
|---|---|
| ID | clostridium-tetani |
| Name | Clostridium tetani |
| Status | active |
| Last reviewed | 2026-06-05 |
| Class | 02-bacteria |
| Family | Clostridiaceae |
| Genus | Clostridium |
| Species | Clostridium tetani |
Cross-Atlas Connections
Sources
- Brüggemann H, Bäumer S, Fricke WF, et al. The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc Natl Acad Sci USA. 2003;100(3):1316-21. · PubMed 12552129
- Montecucco C, Schiavo G. Structure and function of tetanus and botulinum neurotoxins. Q Rev Biophys. 1995;28(4):423-72. · PubMed 8771234
- Popoff MR. Tetanus in animals. J Vet Diagn Invest. 2020;32(2):184-191. · PubMed 32089082
- World Health Organization. Tetanus vaccines: WHO position paper, February 2017. Wkly Epidemiol Rec. 2017;92(6):53-76.
- Chalk CH, Mills KR, Newsom-Davis J. Tetanus. Lancet. 2011. [see also: Rodrigo C, Fernando D, Rajapakse S. Pharmacological management of tetanus: an evidence-based review. Crit Care. 2014;18(2):217.] · PubMed 24661523
- Lalli G, Bohnert S, Deinhardt K, Verastegui C, Schiavo G. The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol. 2003;11(9):431-7. · PubMed 12948668