Atlas Four · Vaccine Atlas · Platform 06 — Toxoid

Tetanus Toxoid (TT / Td / DTaP)

Formaldehyde-inactivated tetanospasmin from *Clostridium tetani*; >95% seroconversion after 3-dose primary series. Protective IgG ≥0.1 IU/mL. Given as TT, Td, DTaP, or DTP. Core WHO EPI vaccine; eliminated neonatal tetanus in >90% of countries. Boosters every 10 years.

Also known as: TT, Td, DTaP, DTP, tetanus toxoid, tetanus vaccine, diphtheria-tetanus-acellular pertussis

06 — ToxoidPlatform
intramuscular (preferred) or subcutaneousRoute
2°C–8°C; do not freeze (freezing destroys adsorbed toxoid)Cold Chain
draftStatus
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tetanus-toxoid

Tetanus Toxoid (TT / Td / DTaP)

Formaldehyde-inactivated tetanospasmin from *Clostridium tetani*; >95% seroconversion after 3-dose primary series. Protective IgG ≥0.1 IU/mL. Given as TT, Td, DTaP, or DTP. Core WHO EPI vaccine; eliminated neonatal tetanus in >90% of countries. Boosters every 10 years.

Entry Metadata

FieldValue
IDtetanus-toxoid
NameTetanus Toxoid (TT / Td / DTaP)
Statusdraft
Last reviewed2026-06-04
Platform06 — Toxoid
Delivery systemIntramuscular or subcutaneous injection; toxoid adsorbed to alum adjuvant (Al(OH)₃ or AlPO₄)
Adjuvantsaluminum hydroxide (alum), aluminum phosphate
Routeintramuscular (preferred) or subcutaneous
Dose — primary series infant dtap3 doses at 2, 4, 6 months (DTaP, diphtheria-tetanus-acellular pertussis)
Dose — booster infantDTaP at 15–18 months and 4–6 years
Dose — adolescent boosterTd (tetanus-diphtheria) at 11–12 years
Dose — adult boostersTd every 10 years; Tdap (with acellular pertussis) once as adult
Dose — wound prophylaxisTT if last dose >5 years before tetanus-prone wound; tetanus immune globulin (TIG) if unvaccinated
DeveloperMultiple WHO-qualified manufacturers (Sanofi Pasteur, GSK, Serum Institute of India, Bio Farma, Biological E., others)
Cold chain2°C–8°C; do not freeze (freezing destroys adsorbed toxoid)
WHO (1974-01-01)WHO Essential Medicines List (EML) — prequalified multiple sources
FDA (1938-01-01)Licensed — multiple formulations (Td, DTaP, Tdap)

Cross-Atlas Connections

elicitsImmune System elicitsT Helper Cell elicitsImmunoglobulin G elicitsB Cell connects-toPeripheral Nerve connects-toSnare Complex

Sources