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snare-complex
SNARE Complex
Core vesicle fusion machinery: synaptobrevin-2 (v-SNARE) + syntaxin-1A + SNAP-25 (t-SNAREs) zipper into a four-helix bundle driving membrane fusion. Cleaved by botulinum/tetanus toxins. Nobel 2013: Sudhof, Rothman, Schekman.
Entry Metadata
| Field | Value |
|---|---|
| ID | snare-complex |
| Name | SNARE Complex |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Sudhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science. 2009;323(5913):474-477. · PubMed 19164740
- Hanson PI, Roth R, Morisaki H, Jahn R, Heuser JE. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell. 1997;90(3):523-535. · PubMed 9267031