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gaba
GABA
γ-Aminobutyric acid — the principal inhibitory neurotransmitter of the brain. Acts via GABA-A (ionotropic Cl⁻ channel) and GABA-B (metabotropic GPCR) receptors. E/I balance governs circuit stability; GABA-A is target of benzodiazepines, barbiturates, and anesthetics.
Entry Metadata
| Field | Value |
|---|---|
| ID | gaba |
| Name | GABA |
| Status | draft |
| Last reviewed | 2026-06-04 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
modulatesNeuron
expressed-byNeuron
modulatesSynapse
modulatesBrain
part-ofNervous System
modulated-byChloride
connects-toEpilepsy
connects-toScn1A
connects-toSchizophrenia
connects-toBipolar Disorder
connects-toAutism Spectrum Disorder
connects-toObsessive Compulsive Disorder
connects-toGeneralized Anxiety Disorder
connects-toPanic Disorder
connects-toSocial Anxiety Disorder
connects-toAlcohol Use Disorder
connects-toOpioid Use Disorder
connects-toInsomnia Disorder
connects-toOrexin
connects-toMu Opioid Receptor
connects-toCrh
connects-toEndocannabinoid
connects-toCannabis Use Disorder
connects-toNpy
connects-toProgesterone
Sources
- Olsen RW, Sieghart W. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Pharmacol Rev. 2008;60(3):243-260. · PubMed 18790874
- Purves D, Augustine GJ, Fitzpatrick D, et al. Neuroscience. 6th ed. Sinauer Associates; 2018.
- Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol. 2006;147(Suppl 1):S109-S119. · PubMed 16402094
- Sieghart W. Allosteric modulation of GABAA receptors via multiple drug-binding sites. Adv Pharmacol. 2015;72:53-96. · PubMed 25600566