Atlas One · Host Biology · Scale 07 — System

Cannabis Use Disorder

Cannabis use disorder (~9% of users) results from THC-driven CB1R desensitization/downregulation; withdrawal: anxiety, irritability, insomnia, appetite loss. Prevalence rising with legalization. No FDA-approved pharmacotherapy; CBT and motivational enhancement are first-line.

Also known as: cannabis use disorder, CUD, marijuana use disorder, cannabis dependence, THC dependence, cannabis withdrawal, marijuana addiction

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
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cannabis-use-disorder

Cannabis Use Disorder

Cannabis use disorder (~9% of users) results from THC-driven CB1R desensitization/downregulation; withdrawal: anxiety, irritability, insomnia, appetite loss. Prevalence rising with legalization. No FDA-approved pharmacotherapy; CBT and motivational enhancement are first-line.

Entry Metadata

FieldValue
IDcannabis-use-disorder
NameCannabis Use Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toEndocannabinoid connects-toDopamine connects-toGaba connects-toBdnf targetsBrain

Sources