Atlas One · Host Biology · Scale 07 — System

Cannabis Use Disorder

Cannabis use disorder (~9% of users) results from THC-driven CB1R desensitization/downregulation; withdrawal: anxiety, irritability, insomnia, appetite loss. Prevalence rising with legalization. No FDA-approved pharmacotherapy; CBT and motivational enhancement are first-line.

Also known as: cannabis use disorder, CUD, marijuana use disorder, cannabis dependence, THC dependence, cannabis withdrawal, marijuana addiction

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

cannabis-use-disorder

Cannabis Use Disorder

Cannabis use disorder (~9% of users) results from THC-driven CB1R desensitization/downregulation; withdrawal: anxiety, irritability, insomnia, appetite loss. Prevalence rising with legalization. No FDA-approved pharmacotherapy; CBT and motivational enhancement are first-line.

Entry Metadata

Field	Value
ID	cannabis-use-disorder
Name	Cannabis Use Disorder
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toEndocannabinoid connects-toDopamine connects-toGaba connects-toBdnf targetsBrain connects-toInternet Gaming Disorder connects-toSchizophrenia connects-toLung connects-toAlcohol Use Disorder connects-toOpioid Use Disorder connects-toGeneralized Anxiety Disorder connects-toStimulant Use Disorder connects-toBipolar Disorder connects-toNeuron connects-toPanic Disorder connects-toMajor Depressive Disorder connects-toPtsd connects-toHeart connects-toInsomnia Disorder connects-toGlutamate connects-toDigestive System connects-toReproductive System connects-toAttention Deficit Hyperactivity Disorder connects-toHippocampus connects-toLiver connects-toAcetylcholine connects-toTestosterone connects-toMicroglia connects-toCortisol connects-toSynapse connects-toLarge Intestine connects-toAstrocyte connects-toAdipocyte connects-toEye connects-toPotassium connects-toPhoton connects-toKidney connects-toOligodendrocyte connects-toStomach connects-toGhrelin connects-toSerotonin connects-toImmune System connects-toMacrophage connects-toMelatonin connects-toStroke connects-toCardiomyocyte connects-toLeptin connects-toCopd connects-toPlacenta connects-toTnf Alpha connects-toNorepinephrine connects-toNervous System connects-toRespiratory System connects-toAspergillus Fumigatus connects-toAsthma connects-toSocial Anxiety Disorder connects-toHeart Failure connects-toNsclc connects-toHnscc connects-toCardiovascular System connects-toBorderline Personality Disorder connects-toObsessive Compulsive Disorder connects-toEndocrine System connects-toIntegumentary System connects-toMusculoskeletal System connects-toRenal System connects-toAspergillus Fumigatus connects-toMycobacterium Tuberculosis connects-toFluoxetine connects-toGambling Disorder connects-toEpilepsy connects-toCancer Chemotherapy connects-toHiv Aids connects-toObesity connects-toCardiac Conduction System connects-toAlveolus connects-toBinge Eating Disorder connects-toArterial Wall connects-toOsteoporosis connects-toAutism Spectrum Disorder connects-toMyocardium connects-toIntestinal Epithelium connects-toAtherosclerosis connects-toMu Opioid Receptor connects-toOxytocin connects-toOrexin connects-toCrh connects-toIl 6 connects-toIl 1B connects-toNpy connects-toSubstance P connects-toAdenosine connects-toIl 10 connects-toNitric Oxide connects-toGrowth Hormone connects-toGlucocorticoid Receptor connects-toErk1 2 connects-toMtor connects-toAkt connects-toActh connects-toNlrp3 Inflammasome connects-toTlr4 connects-toNtrk connects-toNf Kb connects-toGsk 3B connects-toStat3 connects-toGalectin 3 connects-toJak1 2 connects-toStat1 connects-toFoxo connects-toCgas Sting connects-toHif 1Alpha connects-toS100A8 A9 connects-toPik3Ca connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toEstrogen connects-toProlactin connects-toTroponin Complex connects-toInsulin connects-toProgesterone connects-toXanthine Oxidase connects-toGlp 1 connects-toProstaglandins connects-toAldosterone connects-toVasopressin connects-toIl 4 connects-toSerotonin Transporter connects-toIl 13 connects-toHeart connects-toStimulant Use Disorder connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toMast Cell connects-toT Helper Cell connects-toNatural Killer Cell connects-toComplement C3 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toPeriostin connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toSelenium connects-toIodine connects-toSodium connects-toZinc connects-toMagnesium connects-toCalcium connects-toCopper connects-toIron connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr

Sources