Atlas One · Host Biology · Scale 07 — System

Panic Disorder

Panic disorder (2-3% lifetime) involves recurrent unexpected panic attacks driven by LC-NE hyperactivation and amygdala CO2 hypersensitivity; first-line: SSRIs/SNRIs + CBT with interoceptive exposure; benzodiazepines for acute attacks; avoid long-term BZ use.

Also known as: panic disorder, panic attack, agoraphobia, CO2 hypersensitivity, Klein suffocation alarm, interoceptive exposure, unexpected panic, anticipatory anxiety

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
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panic-disorder

Panic Disorder

Panic disorder (2-3% lifetime) involves recurrent unexpected panic attacks driven by LC-NE hyperactivation and amygdala CO2 hypersensitivity; first-line: SSRIs/SNRIs + CBT with interoceptive exposure; benzodiazepines for acute attacks; avoid long-term BZ use.

Entry Metadata

FieldValue
IDpanic-disorder
NamePanic Disorder
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNorepinephrine connects-toSerotonin connects-toGaba connects-toGlutamate targetsBrain connects-toOxytocin treated-byFluoxetine

Sources