Atlas One · Host Biology · Scale 07 — System

Stimulant Use Disorder

Cocaine and amphetamine misuse causing pathological dopamine surges (DAT block/reversal). VTA-NAcc remodeling via ΔFosB accumulation; D2R downregulation; hypodopaminergic withdrawal state. No FDA-approved pharmacotherapy; contingency management has strongest evidence.

Also known as: cocaine use disorder, cocaine addiction, methamphetamine use disorder, stimulant addiction, amphetamine use disorder

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

stimulant-use-disorder

Stimulant Use Disorder

Cocaine and amphetamine misuse causing pathological dopamine surges (DAT block/reversal). VTA-NAcc remodeling via ΔFosB accumulation; D2R downregulation; hypodopaminergic withdrawal state. No FDA-approved pharmacotherapy; contingency management has strongest evidence.

Entry Metadata

Field	Value
ID	stimulant-use-disorder
Name	Stimulant Use Disorder
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toDopamine connects-toNorepinephrine connects-toSerotonin connects-toBdnf connects-toGlutamate connects-toBrain connects-toHeart connects-toOpioid Use Disorder connects-toSchizophrenia connects-toStroke connects-toHiv Aids connects-toAlcohol Use Disorder connects-toCannabis Use Disorder connects-toBipolar Disorder connects-toCardiomyocyte connects-toMajor Depressive Disorder connects-toCardiovascular System connects-toInsomnia Disorder connects-toNeuron connects-toAttention Deficit Hyperactivity Disorder connects-toNervous System connects-toSkin connects-toPlacenta connects-toPanic Disorder connects-toKidney connects-toMicroglia connects-toHypertension connects-toSynapse connects-toEndothelial Cell connects-toLung connects-toPotassium connects-toLarge Intestine connects-toPlatelet connects-toPhoton connects-toSodium connects-toPeripheral Nerve connects-toElectron connects-toLiver connects-toMagnesium connects-toStomach connects-toReproductive System connects-toNeutrophil connects-toSmooth Muscle Cell connects-toEpinephrine connects-toPancreas connects-toHiv connects-toAtherosclerosis connects-toGambling Disorder connects-toAstrocyte connects-toNlrp3 Inflammasome connects-toHepatitis C connects-toNf Kb connects-toCandida Albicans connects-toCkd connects-toHeart Failure connects-toPulmonary Arterial Hypertension connects-toSepsis connects-toWound Healing connects-toStaphylococcus Aureus connects-toPtsd connects-toIntegumentary System connects-toDigestive System connects-toMusculoskeletal System connects-toRespiratory System connects-toEndocrine System connects-toRenal System connects-toImmune System connects-toHepatitis B Virus connects-toClostridium Tetani connects-toCrh connects-toParkinsons Disease connects-toEpilepsy connects-toMyocardium connects-toArterial Wall connects-toAnorexia Nervosa connects-toCardiac Conduction System connects-toEndocardium connects-toAlveolus connects-toHepatitis B connects-toGlomerulus connects-toVenous Thromboembolism connects-toAnca Vasculitis connects-toIntestinal Epithelium connects-toMusculoskeletal System connects-toEndothelin 1 connects-toTnf Alpha connects-toIl 6 connects-toSerotonin Transporter connects-toNitric Oxide connects-toAdenosine connects-toOrexin connects-toGsk 3B connects-toTlr4 connects-toGlp 1 connects-toCaspase 3 connects-toTroponin Complex connects-toErk1 2 connects-toAkt connects-toGlucocorticoid Receptor connects-toMyd88 connects-toMtor connects-toNtrk connects-toPten connects-toGalectin 3 connects-toJak1 2 connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toPik3Ca connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toArid1A connects-toEstrogen connects-toOxytocin connects-toMu Opioid Receptor connects-toAldosterone connects-toInsulin connects-toIl 10 connects-toProstaglandins connects-toXanthine Oxidase connects-toCholesterol connects-toIl 4 connects-toZinc connects-toCopper connects-toIl 13 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toNeuron connects-toOpioid Use Disorder connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toProlactin connects-toVasopressin connects-toSelenium connects-toIodine connects-toPhosphorus connects-toIron connects-toCalcium connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toPd 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toVegf connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr

Sources