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stimulant-use-disorder
Stimulant Use Disorder
Cocaine and amphetamine misuse causing pathological dopamine surges (DAT block/reversal). VTA-NAcc remodeling via ΔFosB accumulation; D2R downregulation; hypodopaminergic withdrawal state. No FDA-approved pharmacotherapy; contingency management has strongest evidence.
Entry Metadata
| Field | Value |
|---|---|
| ID | stimulant-use-disorder |
| Name | Stimulant Use Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Volkow ND, Wang GJ, Fowler JS, Telang F. Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3191-200. · PubMed 18640918
- Robinson TE, Berridge KC. Addiction. Annu Rev Psychol. 2003;54:25-53. · PubMed 12185211
- Prendergast M, Podus D, Finney J, Greenwell L, Roll J. Contingency management for treatment of substance use disorders: a meta-analysis. Addiction. 2006;101(11):1546-60. · PubMed 17034434