This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
bipolar-disorder
Bipolar Disorder
Bipolar disorder (60M affected) causes episodic mania and depression; dopaminergic dysregulation and CLOCK gene variants drive mood cycles; lithium (GSK-3β inhibitor, suicide prevention) is gold-standard mood stabilizer; valproate and quetiapine are alternatives.
Entry Metadata
| Field | Value |
|---|---|
| ID | bipolar-disorder |
| Name | Bipolar Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. Lancet. 2016;387(10027):1561-1572. · PubMed 26388529
- Geddes JR, Miklowitz DJ. Treatment of bipolar disorder. Lancet. 2013;381(9878):1672-1682. · PubMed 23663953
- Cipriani A, Hawton K, Stockton S, Geddes JR. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 2013;346:f3646. · PubMed 23814104