Atlas One · Host Biology · Scale 07 — System

Bipolar Disorder

Bipolar disorder (60M affected) causes episodic mania and depression; dopaminergic dysregulation and CLOCK gene variants drive mood cycles; lithium (GSK-3β inhibitor, suicide prevention) is gold-standard mood stabilizer; valproate and quetiapine are alternatives.

Also known as: bipolar disorder, bipolar I, bipolar II, manic-depressive disorder, mania, hypomania, mood stabilizer, lithium, valproate bipolar

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

bipolar-disorder

Bipolar Disorder

Bipolar disorder (60M affected) causes episodic mania and depression; dopaminergic dysregulation and CLOCK gene variants drive mood cycles; lithium (GSK-3β inhibitor, suicide prevention) is gold-standard mood stabilizer; valproate and quetiapine are alternatives.

Entry Metadata

Field	Value
ID	bipolar-disorder
Name	Bipolar Disorder
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toGsk 3B connects-toDopamine connects-toSerotonin connects-toBdnf connects-toGaba targetsBrain connects-toAutism Spectrum Disorder connects-toSchizophrenia connects-toMajor Depressive Disorder connects-toBorderline Personality Disorder connects-toInsomnia Disorder connects-toAlcohol Use Disorder connects-toCannabis Use Disorder connects-toGeneralized Anxiety Disorder connects-toNeuron connects-toBinge Eating Disorder connects-toPtsd connects-toAnorexia Nervosa connects-toGlutamate connects-toMelatonin connects-toNervous System connects-toThyroid Hormones connects-toKidney connects-toCalcium connects-toSodium connects-toMicroglia connects-toNorepinephrine connects-toCortisol connects-toOligodendrocyte connects-toHippocampus connects-toThyroid connects-toAstrocyte connects-toAtp connects-toPhoton connects-toSynapse connects-toLiver connects-toElectron connects-toHeart connects-toMagnesium connects-toSkin connects-toPancreas connects-toReproductive System connects-toIl 6 connects-toCardiovascular System connects-toLarge Intestine connects-toObesity connects-toAdrenal Gland connects-toTnf Alpha connects-toType 2 Diabetes connects-toEndocannabinoid connects-toT Helper Cell connects-toNf Kb connects-toAtherosclerosis connects-toCkd connects-toStroke connects-toHeart Failure connects-toMigraine connects-toPsoriasis connects-toCopd connects-toFibromyalgia connects-toEndocrine System connects-toDigestive System connects-toPanic Disorder connects-toRenal System connects-toIntegumentary System connects-toImmune System connects-toMusculoskeletal System connects-toRespiratory System connects-toFluoxetine connects-toToxoplasma Gondii connects-toOmega 3 Fatty Acids connects-toSt Johns Wort connects-toAlzheimers Disease connects-toStimulant Use Disorder connects-toAxonal Transport connects-toEpilepsy connects-toGlomerulus connects-toObsessive Compulsive Disorder connects-toParkinsons Disease connects-toCardiac Conduction System connects-toMultiple Sclerosis connects-toPth connects-toCovid 19 Disease connects-toMyocardium connects-toIl 1B connects-toNlrp3 Inflammasome connects-toAcetylcholine connects-toCalcineurin connects-toSerotonin Transporter connects-toMtor connects-toOrexin connects-toNtrk connects-toEstrogen connects-toCalcium connects-toWnt Beta Catenin connects-toInsulin connects-toAkt connects-toErk1 2 connects-toGlucocorticoid Receptor connects-toCrh connects-toPik3Ca connects-toMyd88 connects-toNfe2L2 connects-toGalectin 3 connects-toJak1 2 connects-toStat3 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toAmpk connects-toDnmt3A connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toMdm2 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toAdenosine connects-toComplement C3 connects-toXanthine Oxidase connects-toLeptin connects-toNitric Oxide connects-toProgesterone connects-toAngiotensin Ii connects-toAldosterone connects-toProstaglandins connects-toVasopressin connects-toCholesterol connects-toIl 4 connects-toZinc connects-toCopper connects-toHistamine connects-toAdiponectin connects-toResistin connects-toIl 13 connects-toNeuron connects-toType 2 Diabetes connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toComplement C5 connects-toC5Ar1 connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toErythropoietin connects-toProlactin connects-toTestosterone connects-toOxytocin connects-toSelenium connects-toIodine connects-toPotassium connects-toIron connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toOxygen connects-toPd 1 connects-toGlp 1 connects-toVegf connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toAdrenomedullin connects-toOsteopontin connects-toFgfr connects-toEpinephrine connects-toRenin

Sources