Atlas One · Host Biology · Scale 07 — System

Autism Spectrum Disorder

ASD (1-2% prevalence; 4:1 male bias) causes social communication deficits and restricted repetitive behaviors; E/I imbalance and synaptic scaffold mutations (SHANK3, NLGN3/4) are core mechanisms; ABA therapy is evidence-based; no pharmacotherapy is approved for core symptoms.

Also known as: autism spectrum disorder, ASD, autism, Asperger syndrome, autistic disorder, pervasive developmental disorder, SHANK3, NLGN3, Fragile X, Rett syndrome

Scale 07 — SystemScale

draftStatus

2026-06-08Last Reviewed

This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.

autism-spectrum-disorder

Autism Spectrum Disorder

ASD (1-2% prevalence; 4:1 male bias) causes social communication deficits and restricted repetitive behaviors; E/I imbalance and synaptic scaffold mutations (SHANK3, NLGN3/4) are core mechanisms; ABA therapy is evidence-based; no pharmacotherapy is approved for core symptoms.

Entry Metadata

Field	Value
ID	autism-spectrum-disorder
Name	Autism Spectrum Disorder
Status	draft
Last reviewed	2026-06-08
Atlas	01-human
Scale	07-system

Cross-Atlas Connections

connects-toOxytocin connects-toGlutamate connects-toGaba connects-toMtor targetsBrain connects-toVasopressin connects-toNeuron connects-toEpilepsy connects-toBipolar Disorder connects-toAttention Deficit Hyperactivity Disorder connects-toTuberous Sclerosis Complex connects-toSynapse connects-toSchizophrenia connects-toObsessive Compulsive Disorder connects-toMicroglia connects-toGut Microbiome connects-toAstrocyte connects-toGeneralized Anxiety Disorder connects-toSerotonin connects-toDopamine connects-toNervous System connects-toImmune System connects-toBdnf connects-toHippocampus connects-toTestosterone connects-toPlacenta connects-toZinc connects-toOligodendrocyte connects-toIl 6 connects-toMagnesium connects-toCalcium connects-toLarge Intestine connects-toAtp connects-toPhoton connects-toIron connects-toEye connects-toElectron connects-toVitamin D connects-toHeart connects-toMelatonin connects-toStomach connects-toThyroid connects-toAntibody connects-toMhc Class Ii connects-toReproductive System connects-toIl 17A connects-toMast Cell connects-toNeurofibromatosis Type 1 connects-toEndocannabinoid connects-toRegulatory T Cell connects-toInsomnia Disorder connects-toNf Kb connects-toPten connects-toDigestive System connects-toSocial Anxiety Disorder connects-toMajor Depressive Disorder connects-toObesity connects-toType 2 Diabetes connects-toIron Deficiency Anemia connects-toAnorexia Nervosa connects-toMusculoskeletal System connects-toIntegumentary System connects-toPtsd connects-toCardiovascular System connects-toEndocrine System connects-toRenal System connects-toInfluenza A connects-toMeasles Virus connects-toOmega 3 Fatty Acids connects-toHerpesvirus connects-toCopper connects-toSulforaphane connects-toTargeted Therapy connects-toAxonal Transport connects-toIntestinal Epithelium connects-toCowden Syndrome connects-toNoonan Syndrome connects-toCardiac Conduction System connects-toGerminal Center connects-toNarcolepsy connects-toCortical Bone connects-toCovid 19 Disease connects-toBorderline Personality Disorder connects-toInternet Gaming Disorder connects-toIl 1B connects-toTnf Alpha connects-toIgf 1 connects-toSerotonin Transporter connects-toTsc1 Tsc2 connects-toArid1A connects-toTlr4 connects-toGsk 3B connects-toNtrk connects-toCalcium connects-toComplement C3 connects-toType I Interferon connects-toAkt connects-toErk1 2 connects-toWnt Beta Catenin connects-toPik3Ca connects-toMyd88 connects-toCalcineurin connects-toStat3 connects-toJak1 2 connects-toGalectin 3 connects-toStat1 connects-toCgas Sting connects-toSmad4 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toAmpk connects-toDnmt3A connects-toEzh2 connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toComplement C5 connects-toAdenosine connects-toOsteopontin connects-toCcl2 connects-toEstrogen connects-toNfe2L2 connects-toNitric Oxide connects-toIl 4 connects-toIl 2 connects-toProgesterone connects-toProstaglandins connects-toIl 10 connects-toXanthine Oxidase connects-toIl 13 connects-toHistamine connects-toLeptin connects-toAcetylcholine connects-toAdiponectin connects-toResistin connects-toNeuron connects-toAttention Deficit Hyperactivity Disorder connects-toGut Microbiome connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toT Cytotoxic Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toFactor H connects-toC1 Esterase Inhibitor connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toPeriostin connects-toProlactin connects-toSelenium connects-toIodine connects-toSodium connects-toTransferrin connects-toPotassium connects-toPhosphorus connects-toSulfur connects-toChloride connects-toNitrogen connects-toOxygen connects-toCarbon connects-toNorepinephrine connects-toVegf connects-toPd 1 connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin connects-toAngiopoietin connects-toCortisol

Sources