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autism-spectrum-disorder
Autism Spectrum Disorder
ASD (1-2% prevalence; 4:1 male bias) causes social communication deficits and restricted repetitive behaviors; E/I imbalance and synaptic scaffold mutations (SHANK3, NLGN3/4) are core mechanisms; ABA therapy is evidence-based; no pharmacotherapy is approved for core symptoms.
Entry Metadata
| Field | Value |
|---|---|
| ID | autism-spectrum-disorder |
| Name | Autism Spectrum Disorder |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Maenner MJ, Warren Z, Williams AR, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020. MMWR Surveill Summ. 2023;72(2):1-14. · PubMed 36952216
- Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet. 2018;392(10146):508-520. · PubMed 30078460
- Sanders SJ, Murtha MT, Gupta AR, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012;485(7397):237-241. · PubMed 22495306