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narcolepsy
Narcolepsy
Narcolepsy is a chronic hypersomnia disorder caused by selective loss of orexin (hypocretin) neurons in type 1; HLA-DQB1*06:02 and autoimmune destruction; characterized by EDS, cataplexy, sleep paralysis, and hallucinations. Sodium oxybate, pitolisant, modafinil treat symptoms.
Entry Metadata
| Field | Value |
|---|---|
| ID | narcolepsy |
| Name | Narcolepsy |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
Sources
- Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654-2662. · PubMed 26716917
- Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369(9560):499-511. · PubMed 17292770
- Szakacs Z, Dauvilliers Y, Mikhaylov V, et al. Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017;16(3):200-207. · PubMed 28129985