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narcolepsy
Narcolepsy
Narcolepsy is a chronic hypersomnia disorder caused by selective loss of orexin (hypocretin) neurons in type 1; HLA-DQB1*06:02 and autoimmune destruction; characterized by EDS, cataplexy, sleep paralysis, and hallucinations. Sodium oxybate, pitolisant, modafinil treat symptoms.
Entry Metadata
| Field | Value |
|---|---|
| ID | narcolepsy |
| Name | Narcolepsy |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toOrexin
connects-toHistamine
connects-toDopamine
connects-toSerotonin
targetsBrain
connects-toBdnf
connects-toMelatonin
connects-toT Cytotoxic Cell
connects-toNeuron
connects-toInfluenza
connects-toRegulatory T Cell
connects-toObesity
connects-toMicroglia
connects-toType 1 Diabetes
connects-toMultiple Sclerosis
connects-toMajor Depressive Disorder
connects-toImmune System
connects-toAcetylcholine
connects-toInsomnia Disorder
connects-toNervous System
connects-toStreptococcus Pyogenes
connects-toCardiovascular System
connects-toMhc Class Ii
connects-toT Helper Cell
connects-toNorepinephrine
connects-toGaba
connects-toAdenosine
connects-toDendritic Cell
connects-toSodium
connects-toSynapse
connects-toAstrocyte
connects-toHeart
connects-toPhoton
connects-toAdipocyte
connects-toEye
connects-toLeptin
connects-toGlutamate
connects-toElectron
connects-toPeripheral Nerve
connects-toLarge Intestine
connects-toAntibody
connects-toThyroid
connects-toReproductive System
connects-toThymus
connects-toAttention Deficit Hyperactivity Disorder
connects-toB Cell
connects-toType 2 Diabetes
connects-toHypertension
connects-toGhrelin
connects-toTnf Alpha
connects-toGeneralized Anxiety Disorder
connects-toMigraine
connects-toStat3
connects-toBipolar Disorder
connects-toPanic Disorder
connects-toSchizophrenia
connects-toHeart Failure
connects-toStroke
connects-toBinge Eating Disorder
connects-toEpilepsy
connects-toParkinsons Disease
connects-toEndocrine System
connects-toRespiratory System
connects-toMusculoskeletal System
connects-toDigestive System
connects-toRenal System
connects-toIntegumentary System
connects-toFluoxetine
connects-toStimulant Use Disorder
connects-toPanax Ginseng
connects-toInfluenza A
connects-toHuntingtons Disease
connects-toFibromyalgia
connects-toMyasthenia Gravis
connects-toPtsd
connects-toGuillain Barre
connects-toGambling Disorder
connects-toCardiac Conduction System
connects-toLewy Body Dementia
connects-toCovid 19 Disease
connects-toCortisol
connects-toHippocampus
connects-toIfn Gamma
connects-toType I Interferon
connects-toIl 6
connects-toPerforin
connects-toIl 1B
connects-toNlrp3 Inflammasome
connects-toIl 17A
connects-toCcl2
connects-toInsulin
connects-toInfluenza Ha
connects-toIl 2
connects-toTlr4
connects-toProstaglandins
connects-toGrowth Hormone
connects-toVasopressin
connects-toCtla 4
connects-toIl 10
connects-toTgf Beta
connects-toJak1 2
connects-toMyd88
connects-toIl 23
connects-toAkt
connects-toGalectin 3
connects-toStat1
connects-toCgas Sting
connects-toGsk 3B
connects-toPik3Ca
connects-toFoxo
connects-toS100A8 A9
connects-toErk1 2
connects-toSrc Kinase
connects-toMtor
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toComplement C3
connects-toArid1A
connects-toCalcineurin
connects-toOsteopontin
connects-toPd 1
connects-toIl 12
connects-toNitric Oxide
connects-toIl 13
connects-toGlp 1
connects-toBaff
connects-toNpy
connects-toIl 4
connects-toCholesterol
connects-toCopper
connects-toAdiponectin
connects-toResistin
connects-toCrh
connects-toActh
connects-toIron
connects-toNatural Killer Cell
connects-toPlasma Cell
connects-toIl 5
connects-toMast Cell
connects-toIge
connects-toVitamin D
connects-toSelenium
connects-toProlactin
connects-toOxytocin
connects-toC5Ar1
connects-toComplement C5
connects-toFactor H
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toPeriostin
connects-toTestosterone
connects-toTransferrin
connects-toZinc
connects-toMagnesium
connects-toIodine
connects-toPotassium
connects-toCalcium
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toOxygen
connects-toCarbon
connects-toHydrogen
connects-toAngiotensin Ii
connects-toVegf
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toFgfr
connects-toEpinephrine
connects-toRenin
connects-toMyostatin
connects-toAngiopoietin
connects-toGlucagon
Sources
- Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654-2662. · PubMed 26716917
- Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369(9560):499-511. · PubMed 17292770
- Szakacs Z, Dauvilliers Y, Mikhaylov V, et al. Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017;16(3):200-207. · PubMed 28129985