Atlas One · Host Biology · Scale 07 — System

Huntington Disease

Huntington disease is caused by HTT CAG repeat expansion (≥36 copies); autosomal dominant; choreoathetosis, cognitive decline, and psychiatric disturbance onset in the 4th-5th decade; disease-modifying HTT-lowering therapies (ASOs, siRNA) are in Phase 3 clinical trials.

Also known as: Huntington disease, HD, Huntington's disease, HTT CAG expansion, huntingtin disease, chorea HD, polyQ neurodegeneration, HD neurodegeneration, CAG repeat disease, HTT repeat expansion

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
huntingtons-disease

Huntington Disease

Huntington disease is caused by HTT CAG repeat expansion (≥36 copies); autosomal dominant; choreoathetosis, cognitive decline, and psychiatric disturbance onset in the 4th-5th decade; disease-modifying HTT-lowering therapies (ASOs, siRNA) are in Phase 3 clinical trials.

Entry Metadata

FieldValue
IDhuntingtons-disease
NameHuntington Disease
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toHtt connects-toAutophagy connects-toDopamine connects-toCaspase 3 connects-toBdnf connects-toGlutamate targetsBrain connects-toNeuron connects-toMicroglia connects-toNervous System connects-toAstrocyte connects-toParkinsons Disease connects-toMajor Depressive Disorder connects-toAlzheimers Disease connects-toGaba connects-toSchizophrenia connects-toAls connects-toHeart connects-toSerotonin connects-toAcetylcholine connects-toReproductive System connects-toCardiovascular System connects-toDigestive System connects-toSynapse connects-toCalcium connects-toAtp connects-toOligodendrocyte connects-toCholesterol connects-toIron connects-toLarge Intestine connects-toNf Kb connects-toPancreas connects-toAdipocyte connects-toTnf Alpha connects-toPhoton connects-toHippocampus connects-toT Helper Cell connects-toElectron connects-toEye connects-toLung connects-toStomach connects-toMelatonin connects-toMusculoskeletal System connects-toCopper connects-toTestosterone connects-toObsessive Compulsive Disorder connects-toType 2 Diabetes connects-toMtor connects-toMacrophage connects-toComplement C3 connects-toInsomnia Disorder connects-toSepsis connects-toNlrp3 Inflammasome connects-toBipolar Disorder connects-toCardiomyocyte connects-toHeart Failure connects-toOsteoporosis connects-toGeneralized Anxiety Disorder connects-toStreptococcus Pneumoniae connects-toWound Healing connects-toEpilepsy connects-toRespiratory System connects-toEndocrine System connects-toGut Microbiome connects-toCardiovascular System connects-toImmune System connects-toRenal System connects-toFluoxetine connects-toLewy Body Dementia connects-toIntegumentary System connects-toCortisol connects-toStaphylococcus Aureus connects-toNarcolepsy connects-toAxonal Transport connects-toMyocardium connects-toAnorexia Nervosa connects-toCardiac Conduction System connects-toCortical Bone connects-toIntestinal Epithelium connects-toAlveolus connects-toSystemic Lupus Erythematosus connects-toStroke connects-toMlh1 connects-toNfe2L2 connects-toP53 connects-toIl 6 connects-toIl 1B connects-toNorepinephrine connects-toCcl2 connects-toCgas Sting connects-toIgf 1 connects-toMsh2 connects-toNtrk connects-toTlr4 connects-toCalcium connects-toGalectin 3 connects-toXanthine Oxidase connects-toAkt connects-toAmpk connects-toBcl 2 connects-toMyd88 connects-toJak1 2 connects-toErk1 2 connects-toGsk 3B connects-toPten connects-toStat3 connects-toStat1 connects-toFoxo connects-toSmad4 connects-toS100A8 A9 connects-toHif 1Alpha connects-toCdk4 6 connects-toPik3Ca connects-toDnmt3A connects-toMdm2 connects-toSrc Kinase connects-toCcr5 connects-toCalcineurin connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toInsulin connects-toLeptin connects-toMhc Class Ii connects-toTroponin Complex connects-toNitric Oxide connects-toGlp 1 connects-toProstaglandins connects-toIl 10 connects-toMagnesium connects-toIl 4 connects-toIl 13 connects-toZinc connects-toAdiponectin connects-toType I Interferon connects-toResistin connects-toIfn Gamma connects-toIl 12 connects-toT Cytotoxic Cell connects-toIl 5 connects-toIl 23 connects-toDendritic Cell connects-toIge connects-toMast Cell connects-toNatural Killer Cell connects-toC5Ar1 connects-toComplement C5 connects-toTransferrin connects-toFactor H connects-toVitamin D connects-toBradykinin connects-toTslp connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toHistamine connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toOxygen connects-toPd 1 connects-toAngiotensin Ii connects-toVegf connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine connects-toRenin connects-toMyostatin

Sources