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als
ALS
ALS (30k US; 200k global) is a fatal motor neuron disease with progressive degeneration of upper and lower motor neurons; TDP-43 inclusions are the pathological hallmark in >97%; riluzole and edaravone extend survival modestly; tofersen (SOD1 ASO) is approved for familial ALS.
Entry Metadata
| Field | Value |
|---|---|
| ID | als |
| Name | ALS |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toTdp 43
connects-toGlutamate
connects-toMtor
targetsBrain
connects-toAstrocyte
connects-toMicroglia
connects-toPeripheral Nerve
connects-toNeuron
connects-toCidp
connects-toAlzheimers Disease
connects-toNeuromuscular Junction
connects-toMusculoskeletal System
connects-toRespiratory System
connects-toMyasthenia Gravis
connects-toParkinsons Disease
connects-toOligodendrocyte
connects-toAcetylcholine
connects-toLung
connects-toMultiple Sclerosis
connects-toCopper
connects-toNervous System
connects-toImmune System
connects-toAutophagy
connects-toZinc
connects-toGut Microbiome
connects-toCalcium
connects-toRegulatory T Cell
connects-toHippocampus
connects-toAtp
connects-toT Cytotoxic Cell
connects-toSodium
connects-toSynapse
connects-toMacrophage
connects-toTnf Alpha
connects-toPhoton
connects-toIron
connects-toStomach
connects-toElectron
connects-toEye
connects-toLarge Intestine
connects-toSmooth Muscle Cell
connects-toAntibody
connects-toAdipocyte
connects-toEndocannabinoid
connects-toMajor Depressive Disorder
connects-toCardiomyocyte
connects-toVegf
connects-toNeutrophil
connects-toHuntingtons Disease
connects-toTbk1
connects-toNlrp3 Inflammasome
connects-toVenous Thromboembolism
connects-toNf Kb
connects-toSepsis
connects-toInsomnia Disorder
connects-toOsteoporosis
connects-toGeneralized Anxiety Disorder
connects-toCkd
connects-toStreptococcus Pneumoniae
connects-toWound Healing
connects-toNeuropathic Pain
connects-toDigestive System
connects-toEndocrine System
connects-toCardiovascular System
connects-toIntegumentary System
connects-toRenal System
connects-toReproductive System
connects-toHiv 1
connects-toWest Nile Virus
connects-toCoxsackievirus B
connects-toLewy Body Dementia
connects-toEndothelial Cell
connects-toObesity
connects-toTargeted Therapy
connects-toAxonal Transport
connects-toCortical Bone
connects-toAlveolus
connects-toNfe2L2
connects-toType 2 Diabetes
connects-toSchizophrenia
connects-toBipolar Disorder
connects-toCovid 19 Disease
connects-toBdnf
connects-toIgf 1
connects-toIntestinal Epithelium
connects-toCgas Sting
connects-toIl 1B
connects-toIl 6
connects-toCcl2
connects-toType I Interferon
connects-toComplement C3
connects-toCaspase 3
connects-toNitric Oxide
connects-toTlr4
connects-toCalcium
connects-toXanthine Oxidase
connects-toGalectin 3
connects-toAkt
connects-toConnexin43
connects-toBcl 2
connects-toMyd88
connects-toJak1 2
connects-toNtrk
connects-toStat3
connects-toErk1 2
connects-toPten
connects-toStat1
connects-toGsk 3B
connects-toSmad4
connects-toFoxo
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toAmpk
connects-toPik3Ca
connects-toPerforin
connects-toSrc Kinase
connects-toDnmt3A
connects-toCcr5
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toArid1A
connects-toAdenosine
connects-toOsteopontin
connects-toMhc Class Ii
connects-toEstrogen
connects-toInsulin
connects-toIl 2
connects-toCholesterol
connects-toProgesterone
connects-toProstaglandins
connects-toIl 10
connects-toLeptin
connects-toIl 4
connects-toIl 13
connects-toMagnesium
connects-toAdiponectin
connects-toResistin
connects-toSelenium
connects-toAstrocyte
connects-toPeripheral Nerve
connects-toCopper
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toNatural Killer Cell
connects-toC5Ar1
connects-toComplement C5
connects-toMast Cell
connects-toFactor H
connects-toTransferrin
connects-toDendritic Cell
connects-toTslp
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toHistamine
connects-toMelatonin
connects-toErythropoietin
connects-toTestosterone
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toIodine
connects-toPotassium
connects-toPhosphorus
connects-toNitrogen
connects-toChloride
connects-toSulfur
connects-toOxygen
connects-toCarbon
connects-toHydrogen
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toFibronectin
connects-toNotch
connects-toActivin A
connects-toCgrp
connects-toCalcitonin
connects-toTgf Beta
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toFgfr
connects-toEpinephrine
Sources
- Brown RH, Al-Chalabi A. Amyotrophic lateral sclerosis. N Engl J Med. 2017;377(2):162-172. · PubMed 28700839
- Writing Group on behalf of the Edaravone ALS 19 Study Group. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017;16(7):505-512. · PubMed 28522180
- Miller TM, Cudkowicz ME, Genge A, et al. Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med. 2022;387(12):1099-1110. · PubMed 36129998