Atlas One · Host Biology · Scale 07 — System

ALS

ALS (30k US; 200k global) is a fatal motor neuron disease with progressive degeneration of upper and lower motor neurons; TDP-43 inclusions are the pathological hallmark in >97%; riluzole and edaravone extend survival modestly; tofersen (SOD1 ASO) is approved for familial ALS.

Also known as: ALS, amyotrophic lateral sclerosis, Lou Gehrig's disease, motor neuron disease, MND, SOD1 ALS, TDP-43 ALS, C9orf72 ALS, FALS, SALS

Scale 07 — SystemScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
als

ALS

ALS (30k US; 200k global) is a fatal motor neuron disease with progressive degeneration of upper and lower motor neurons; TDP-43 inclusions are the pathological hallmark in >97%; riluzole and edaravone extend survival modestly; tofersen (SOD1 ASO) is approved for familial ALS.

Entry Metadata

FieldValue
IDals
NameALS
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toTdp 43 connects-toGlutamate connects-toMtor targetsBrain connects-toAstrocyte connects-toMicroglia connects-toPeripheral Nerve connects-toNeuron connects-toCidp connects-toAlzheimers Disease connects-toNeuromuscular Junction connects-toMusculoskeletal System connects-toRespiratory System connects-toMyasthenia Gravis connects-toParkinsons Disease connects-toOligodendrocyte connects-toAcetylcholine connects-toLung connects-toMultiple Sclerosis connects-toCopper connects-toNervous System connects-toImmune System connects-toAutophagy connects-toZinc connects-toGut Microbiome connects-toCalcium connects-toRegulatory T Cell connects-toHippocampus connects-toAtp connects-toT Cytotoxic Cell connects-toSodium connects-toSynapse connects-toMacrophage connects-toTnf Alpha connects-toPhoton connects-toIron connects-toStomach connects-toElectron connects-toEye connects-toLarge Intestine connects-toSmooth Muscle Cell connects-toAntibody connects-toAdipocyte connects-toEndocannabinoid connects-toMajor Depressive Disorder connects-toCardiomyocyte connects-toVegf connects-toNeutrophil connects-toHuntingtons Disease connects-toTbk1 connects-toNlrp3 Inflammasome connects-toVenous Thromboembolism connects-toNf Kb connects-toSepsis connects-toInsomnia Disorder connects-toOsteoporosis connects-toGeneralized Anxiety Disorder connects-toCkd connects-toStreptococcus Pneumoniae connects-toWound Healing connects-toNeuropathic Pain connects-toDigestive System connects-toEndocrine System connects-toCardiovascular System connects-toIntegumentary System connects-toRenal System connects-toReproductive System connects-toHiv 1 connects-toWest Nile Virus connects-toCoxsackievirus B connects-toLewy Body Dementia connects-toEndothelial Cell connects-toObesity connects-toTargeted Therapy connects-toAxonal Transport connects-toCortical Bone connects-toAlveolus connects-toNfe2L2 connects-toType 2 Diabetes connects-toSchizophrenia connects-toBipolar Disorder connects-toCovid 19 Disease connects-toBdnf connects-toIgf 1 connects-toIntestinal Epithelium connects-toCgas Sting connects-toIl 1B connects-toIl 6 connects-toCcl2 connects-toType I Interferon connects-toComplement C3 connects-toCaspase 3 connects-toNitric Oxide connects-toTlr4 connects-toCalcium connects-toXanthine Oxidase connects-toGalectin 3 connects-toAkt connects-toConnexin43 connects-toBcl 2 connects-toMyd88 connects-toJak1 2 connects-toNtrk connects-toStat3 connects-toErk1 2 connects-toPten connects-toStat1 connects-toGsk 3B connects-toSmad4 connects-toFoxo connects-toS100A8 A9 connects-toHif 1Alpha connects-toAmpk connects-toPik3Ca connects-toPerforin connects-toSrc Kinase connects-toDnmt3A connects-toCcr5 connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toArid1A connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toEstrogen connects-toInsulin connects-toIl 2 connects-toCholesterol connects-toProgesterone connects-toProstaglandins connects-toIl 10 connects-toLeptin connects-toIl 4 connects-toIl 13 connects-toMagnesium connects-toAdiponectin connects-toResistin connects-toSelenium connects-toAstrocyte connects-toPeripheral Nerve connects-toCopper connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toNatural Killer Cell connects-toC5Ar1 connects-toComplement C5 connects-toMast Cell connects-toFactor H connects-toTransferrin connects-toDendritic Cell connects-toTslp connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toMelatonin connects-toErythropoietin connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toPotassium connects-toPhosphorus connects-toNitrogen connects-toChloride connects-toSulfur connects-toOxygen connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toNotch connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toTgf Beta connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toFgfr connects-toEpinephrine