Atlas One · Host Biology · Scale 03 — Molecular

TDP-43

TDP-43 (TARDBP) is a nuclear RNA-binding protein that regulates pre-mRNA splicing and stability; nuclear clearance and cytoplasmic ubiquitinated inclusions are the pathological hallmark of >97% of ALS and ~45% of FTLD; TARDBP mutations cause ~4% of familial ALS.

Also known as: TDP-43, TARDBP, TAR DNA-binding protein 43, transactive response DNA-binding protein, TDP-43 proteinopathy, ALS pathology

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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tdp-43

TDP-43

TDP-43 (TARDBP) is a nuclear RNA-binding protein that regulates pre-mRNA splicing and stability; nuclear clearance and cytoplasmic ubiquitinated inclusions are the pathological hallmark of >97% of ALS and ~45% of FTLD; TARDBP mutations cause ~4% of familial ALS.

Entry Metadata

FieldValue
IDtdp-43
NameTDP-43
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toAls connects-toMtor connects-toAlzheimers Disease connects-toLewy Body Dementia connects-toBrain

Sources