Atlas One · Host Biology · Scale 03 — Molecular

TBK1

TBK1 (TANK-binding kinase 1; NAK) is the shared kinase activated by MAVS and STING → Ser172 autophosphorylation → IRF3 Ser396 → IFN-β; TBK1 LOF causes familial ALS/FTD; synthetic lethal with KRAS; amlexanox inhibits TBK1/IKKε for metabolic syndrome.

Also known as: TBK1, TANK-binding kinase 1, NAK, T2K, innate kinase TBK1, TBK1-IRF3 axis, TBK1 ALS, IKKε, IRF3 kinase

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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tbk1

TBK1

TBK1 (TANK-binding kinase 1; NAK) is the shared kinase activated by MAVS and STING → Ser172 autophosphorylation → IRF3 Ser396 → IFN-β; TBK1 LOF causes familial ALS/FTD; synthetic lethal with KRAS; amlexanox inhibits TBK1/IKKε for metabolic syndrome.

Entry Metadata

FieldValue
IDtbk1
NameTBK1
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMavs connects-toCgas Sting connects-toIrf3 connects-toNf Kb connects-toRig I

Sources