Atlas One · Host Biology · Scale 03 — Molecular

RIG-I

RIG-I (DDX58; DExD/H-box helicase) senses cytosolic 5′ppp ssRNA and blunt-ended dsRNA ≤300 bp → TRIM25 K63-ubiquitination of CARD1 Lys172 → MAVS CARD-CARD interaction → TBK1 → IRF3 → IFN-β; NS1 (influenza) and NS4B (dengue) inhibit RIG-I; MDA5 senses long dsRNA in parallel.

Also known as: RIG-I, DDX58, retinoic acid-inducible gene I, RIG-I helicase, RIG-I/MDA5, cytosolic RNA sensor, RIGI, innate RNA helicase, antiviral helicase, 5-ppp RNA sensor, DExD-H box

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
rig-i

RIG-I

RIG-I (DDX58; DExD/H-box helicase) senses cytosolic 5′ppp ssRNA and blunt-ended dsRNA ≤300 bp → TRIM25 K63-ubiquitination of CARD1 Lys172 → MAVS CARD-CARD interaction → TBK1 → IRF3 → IFN-β; NS1 (influenza) and NS4B (dengue) inhibit RIG-I; MDA5 senses long dsRNA in parallel.

Entry Metadata

FieldValue
IDrig-i
NameRIG-I
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMavs connects-toIrf3 connects-toInfluenza connects-toZika Virus

Sources