Atlas One · Host Biology · Scale 03 — Molecular

IRF3

IRF3 (interferon regulatory factor 3) is activated by TBK1/IKKε (downstream of MAVS or STING) → C-terminal Ser396/398/402/405 phosphorylation → IRF3 homodimerization → nuclear translocation → IFN-β enhanceosome (IRF3 + NF-κB + AP-1); HCV NS5A and picornavirus 3C inhibit IRF3.

Also known as: IRF3, interferon regulatory factor 3, IFN-beta transcription factor, TBK1-IRF3 axis, IRF3 phosphorylation, IFN-beta enhanceosome, PRDI-III, innate transcription factor

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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irf3

IRF3

IRF3 (interferon regulatory factor 3) is activated by TBK1/IKKε (downstream of MAVS or STING) → C-terminal Ser396/398/402/405 phosphorylation → IRF3 homodimerization → nuclear translocation → IFN-β enhanceosome (IRF3 + NF-κB + AP-1); HCV NS5A and picornavirus 3C inhibit IRF3.

Entry Metadata

FieldValue
IDirf3
NameIRF3
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toMavs connects-toCgas Sting connects-toType I Interferon connects-toHepatitis C connects-toNf Kb

Sources