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chloride
Chloride
Chloride (Cl⁻, atomic number 17) — plasma 103 mEq/L, principal extracellular anion. Drives GABA-A inhibition, gastric HCl, CFTR fluid secretion, and CO₂ transport (chloride shift/AE1). Mutations in CFTR, NKCC2, or NCC cause cystic fibrosis, Bartter, or Gitelman syndrome.
Entry Metadata
| Field | Value |
|---|---|
| ID | chloride |
| Name | Chloride |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Atlas | 01-human |
| Scale | 02-atomic |
Cross-Atlas Connections
Sources
- Berg JM, Tymoczko JL, Stryer L. Biochemistry. 9th ed. W.H. Freeman; 2019.
- Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021.
- Csanady L, Vergani P, Gadsby DC. Structure, gating, and regulation of the CFTR anion channel. Physiol Rev. 2019;99(1):707-738. · PubMed 30516487
- Ben-Ari Y. Excitatory actions of GABA during development: the nature of the nurture. Nat Rev Neurosci. 2002;3(9):728-39. · PubMed 12209121