Atlas One · Host Biology · Scale 03 — Molecular

CFTR

CFTR is an ATP-gated chloride and bicarbonate channel; F508del (most common CF mutation) causes protein misfolding and ER retention → absent surface expression → thick mucus; CFTR modulators (elexacaftor/tezacaftor/ivacaftor) restore partial function in F508del homozygotes.

Also known as: CFTR, cystic fibrosis transmembrane conductance regulator, ABCC7, CFTR channel, CFTR F508del, CFTR modulator, CFTR ivacaftor, CFTR chloride channel, CFTR corrector, CFTR potentiator

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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cftr

CFTR

CFTR is an ATP-gated chloride and bicarbonate channel; F508del (most common CF mutation) causes protein misfolding and ER retention → absent surface expression → thick mucus; CFTR modulators (elexacaftor/tezacaftor/ivacaftor) restore partial function in F508del homozygotes.

Entry Metadata

FieldValue
IDcftr
NameCFTR
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCystic Fibrosis connects-toPrss1 connects-toTgf Beta connects-toNlrp3 Inflammasome connects-toPancreatic Cancer connects-toNf Kb connects-toTnf Alpha

Sources