Atlas One · Host Biology · Scale 03 — Molecular

PRSS1

PRSS1 (cationic trypsinogen) is the predominant pancreatic zymogen; R122H blocks autolytic self-inactivation and N29I disrupts calcium stabilization → both cause premature/persistent trypsin activation → hereditary pancreatitis; PRSS1 GOF mutations are autosomal dominant.

Also known as: PRSS1, cationic trypsinogen, trypsinogen 1, PRSS1 hereditary pancreatitis, PRSS1 R122H, PRSS1 N29I, PRSS1 pancreatitis, trypsinogen PRSS1, cationic trypsinogen R122H

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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prss1

PRSS1

PRSS1 (cationic trypsinogen) is the predominant pancreatic zymogen; R122H blocks autolytic self-inactivation and N29I disrupts calcium stabilization → both cause premature/persistent trypsin activation → hereditary pancreatitis; PRSS1 GOF mutations are autosomal dominant.

Entry Metadata

FieldValue
IDprss1
NamePRSS1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHereditary Pancreatitis connects-toPancreatic Cancer connects-toKras connects-toTgf Beta

Sources