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autophagy
Autophagy
Lysosomal self-digestion pathway; ULK1 initiates phagophore formation, LC3 lipidation seals it, SQSTM1/p62 links ubiquitinated cargo. mTORC1 suppresses; AMPK activates. Roles in cancer survival, neurodegeneration, immunity, and antibiotic resistance via xenophagy.
Entry Metadata
| Field | Value |
|---|---|
| ID | autophagy |
| Name | Autophagy |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 2011;27:107-132. · PubMed 21801009
- Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323-335. · PubMed 21248839
- Galluzzi L, Pietrocola F, Bravo-San Pedro JM, et al. Autophagy in malignant transformation and cancer progression. EMBO J. 2015;34(7):856-880. · PubMed 25712477