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oxytocin
Oxytocin
Oxytocin (9-aa neuropeptide from paraventricular and supraoptic hypothalamic nuclei) mediates uterine contraction, lactation, pair bonding, and social trust via OTR/Gαq signaling; reduces amygdala fear reactivity; investigated for autism spectrum disorder and PTSD.
Entry Metadata
| Field | Value |
|---|---|
| ID | oxytocin |
| Name | Oxytocin |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG, Gordon S. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. J Am Chem Soc. 1953;75(19):4879-4880. · PubMed 13100192
- Insel TR, Young LJ. The neurobiology of attachment. Nat Rev Neurosci. 2001;2(2):129-136. · PubMed 11252992
- Yamasue H, Domes G. Oxytocin and autism spectrum disorders. Curr Top Behav Neurosci. 2017;35:449-465. · PubMed 28097578