Atlas One · Host Biology · Scale 03 — Molecular

TLR4

TLR4 (Toll-like receptor 4; CD284; type I TM PAMP receptor) senses gram-negative LPS via MD-2/CD14 → MyD88/TRIF → NF-κB/IRF3 → TNF-α, IL-12, IFN-β; TLR4 Asp299Gly/Thr399Ile SNPs → hyporesponsiveness and sepsis risk; antagonists (TAK-242) suppress endotoxin-driven inflammation.

Also known as: Toll-like receptor 4, CD284, TLR-4, LPS receptor, endotoxin receptor, ARMD10, TOLL

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
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tlr4

TLR4

TLR4 (Toll-like receptor 4; CD284; type I TM PAMP receptor) senses gram-negative LPS via MD-2/CD14 → MyD88/TRIF → NF-κB/IRF3 → TNF-α, IL-12, IFN-β; TLR4 Asp299Gly/Thr399Ile SNPs → hyporesponsiveness and sepsis risk; antagonists (TAK-242) suppress endotoxin-driven inflammation.

Entry Metadata

FieldValue
IDtlr4
NameTLR4
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toLeishmaniasis connects-toSepsis regulatesNf Kb connects-toMyd88 regulatesTnf Alpha

Sources